cADPR-sensitive calcium-release channel activity

[gocentral]

Pharmacological studies indicate that ryanodine receptors are the intracellular Ca2+ channels involved in cADPR induced Ca2+ release. see PubMed 11752598. maybe consider this paragraph in PubMed:10759027 In several mammalian cell types the effects of cADPR on RyR have been described. The type 3 RyR is expressed in the brain, but also in peripheral tissue such as human Jurkat T-lymphocytes [37, 54, 55] and rat diaphragm muscle [56]. In all three cell/tissue types, specific effects of cADPR on the RyR have been observed, either (a) as an increase in single channel openings in reconstituted lipid planar bilayers [22], (b) as release of [45Ca2+] from brain microsomes [22], (c) as a stimulatory effect on the velocity of [3H]ryanodine binding to T cell membranes [37], or (d) as shift in the open probability of the RyR/Ca2+ channel towards lower Ca2+ concentrations in diaphragm muscle [56]. The type 2 RyR, found mainly in cardiac muscle, also responded to cADPR in lipid planar bilayer experiments as well as by release of [45Ca2+] from microsomes [22]. Recently, specific effects of photoreleased cADPR on the magnitude of whole-cell Ca2+ transients and on the frequency of Ca2+ sparks have been reported for cardiac myocytes [57]. Also in PC12 cells, which express mainly the type 2 RyR, Ca2+ release by cADPR was observed in permeabilized cell preparations [40]. See essentially PubMed: 8391127 and 8663443

Reported by: silviabraconi

Original Ticket: geneontology/ontology-requests/7921

[gocentral]

• assigned_to: nobody --> gomidori

Original comment by: mah11

[gocentral]

added cADPR-sensitive calcium-release channel activity GO:0072346

Original comment by: mah11

[gocentral]

• status: open --> closed-accepted

Original comment by: mah11