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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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AP-3 adaptor complex binding #8297

Closed gocentral closed 9 years ago

gocentral commented 13 years ago

Ontology Molecular Function Definition Interacting selectively and non-covalently with the AP3-adaptor complex. The AP3-adaptor complex is an AP-type membrane coat adaptor complex not associated with clathrin that consists of delta, beta3, mu3 and sigma3 subunits that is involved in organelle biogenesis of melanosomes, platelet dense granules and lysosomes.

Position in ontology: child of GO:0030119 AP-type membrane coat adaptor complex PUBMED:16162817

Reported by: astutz

Original Ticket: geneontology/ontology-requests/8084

gocentral commented 13 years ago

Original comment by: rebeccafoulger

gocentral commented 13 years ago

Correction:

AP-3 adaptor complex binding Molecular Function Interacting selectively and non-covalently with the AP3-adaptor complex(es). The AP3-adaptor complex is an AP-type membrane coat adaptor complex that consists of delta, beta3 (beta3A, beta3B isotypes), mu3 (mu3A and mu3C) and sigma3 (sigma3A and sigma3B isotypes) subunits and links clathrin to the membrane surface of a vesicle.

Position in ontology: child of GO:0043234 protein complex PUBMED:16162817

Original comment by: astutz

gocentral commented 13 years ago

Created new function term:

AP-3 adaptor complex binding ; GO:0035651 Interacting selectively and non-covalently with the AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).

In at least yeast, the AP-3 complex can't bind clathrin. I've updated the cellular component term to add in the variant information, but haven't moved it to a clathrin-component parent.

Thanks, Becky

Original comment by: rebeccafoulger

gocentral commented 13 years ago

Original comment by: rebeccafoulger