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Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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AP-2 adaptor complex binding #8301

Closed gocentral closed 9 years ago

gocentral commented 13 years ago

GO:0035612

Change Molecular Function definition to:

Interacting selectively and non-covalently with the AP2-adaptor complex(es). The AP2-adaptor complex is an AP-type membrane coat adaptor complex that consists of alpha (alphaA and alphaB isotypes), beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle.

Position in ontology: child of GO:0043234 protein complex PUBMED:16162817 and 21097499

Reported by: astutz

Original Ticket: geneontology/ontology-requests/8088

gocentral commented 13 years ago

Original comment by: rebeccafoulger

gocentral commented 13 years ago

Hello Andre,

Are the isotypes specific to human? The AP-adaptor complexes are found across species, so the definitions need to allow for that.

AP-2 adaptor complex binding ; GO:0035612 is also a molecular function term. It has the parent 'protein complex binding ; GO:0032403.

protein complex ; GO:0043234 is a cellular component term and is intended for members of the complex itself. It can't be a parent to GO:0035612.

Thanks, Becky

Original comment by: rebeccafoulger

gocentral commented 13 years ago

Updated definitions of the cellular component and molecular function terms to:

AP-2 adaptor complex ; GO:0030122 A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). PMID:21097499

AP-2 adaptor complex binding ; GO:0035612 Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). PMID:21097499

The binding terms are in the molecular function ontology, and the complex terms themselves are in the cellular component ontology. There are not yet links between the two.

Thanks, Becky

Original comment by: rebeccafoulger

gocentral commented 13 years ago

Original comment by: rebeccafoulger