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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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a few terms with general names and very specific reactions #8361

Closed gocentral closed 9 years ago

gocentral commented 13 years ago

Hello,

I'm submitting these terms for review because their name implies a more generalized reaction yet their definitions (and sometimes "exact" synonyms) are more specific.

1) 20-alpha-hydroxysteroid dehydrogenase activity

GO:0047006 Ontology Molecular Function Synonyms related: 20alpha-HSD related: 20alpha-HSDH exact: 20alpha-hydroxy steroid dehydrogenase activity broad: 20alpha-hydroxysteroid dehydrogenase exact: 20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity Definition Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone. Source: EC:1.1.1.149, MetaCyc:1.1.1.149-RXN

2) transaldolase activity

GO:0004801 Ontology Molecular Function Synonyms exact: dihydroxyacetone transferase activity exact: dihydroxyacetonetransferase activity exact: glycerone transferase activity exact: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity Definition Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. Source: EC:2.2.1.2

3) 3(or 17)beta-hydroxysteroid dehydrogenase activity GO:0030283 Ontology Molecular Function Synonyms exact: 17beta-hydroxy steroid dehydrogenase exact: 3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase exact: 3beta-hydroxy steroid dehydrogenase exact: 3beta-hydroxysteroid dehydrogenase exact: beta-hydroxy steroid dehydrogenase Definition Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. Source: EC:1.1.1.51

4) 3(or 17)-alpha-hydroxysteroid dehydrogenase activity

GO:0047023 Ontology Molecular Function Synonyms exact: 3(17)alpha-hydroxysteroid dehydrogenase activity exact: 3(or 17)alpha-hydroxysteroid dehydrogenase activity exact: 3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity Definition Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. Source: EC:1.1.1.209, MetaCyc:1.1.1.209-RXN

5) 3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity GO:0047044 Ontology Molecular Function Synonyms exact: (R)-20-hydroxysteroid dehydrogenase activity related: 20beta-HSD exact: 20beta-hydroxysteroid dehydrogenase activity exact: 3alpha(or 20beta)-hydroxysteroid dehydrogenase activity exact: 3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity exact: 3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity exact: cortisone reductase activity exact: dehydrogenase, 20beta-hydroxy steroid exact: delta4-3-ketosteroid hydrogenase activity exact: NADH-20beta-hydroxysteroid dehydrogenase activity Definition Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. Source: EC:1.1.1.53, MetaCyc:1.1.1.53-RXN Comment None

6) 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity GO:0047035 Ontology Molecular Function Synonyms related: 3alpha(17beta)-HSD exact: 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) exact: 3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity exact: 3alpha,17beta-hydroxy steroid dehydrogenase activity Definition Catalysis of the reaction: NAD+ + testosterone = NADH + H+ + androst-4-ene-3,17-dione. Source: EC:1.1.1.239, MetaCyc:1.1.1.239-RXN

Sincerely, kate

Reported by: kadreher

Original Ticket: geneontology/ontology-requests/8148

gocentral commented 13 years ago

Original comment by: mah11

gocentral commented 13 years ago

I've renamed all of these so the name and definition represent the same specificity; if there was a synonym that matches the definition, I used it as the name. The old name is now a broad synonym in each case, and I've adjusted other synonym scopes as needed.

We can also add new terms if we need a generic parent (matching the old name) or a different specific term, but we'll do that as and when they're requested.

New names (your list, plus other siblings I noticed): GO:0047006 -> 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity GO:0004801 -> sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity GO:0030283 -> 3(or 17)beta-testosterone dehydrogenase activity GO:0047023 -> 3(or 17)-alpha-androsterone dehydrogenase activity GO:0047044 -> 3-alpha(or 20-beta)-androstan-3-alpha,17-beta-diol dehydrogenase activity GO:0047035 -> 3-alpha(17-beta)-testosterone dehydrogenase (NAD+) activity

GO:0047013 -> cholate 12-alpha-dehydrogenase activity GO:0047521 -> 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity GO:0047007 -> pregnan-21-ol dehydrogenase (NAD+) activity GO:0047008 -> pregnan-21-ol dehydrogenase (NADP+) activity GO:0047026 -> androsterone dehydrogenase (A-specific) activity GO:0047042 -> androsterone dehydrogenase (B-specific) activity GO:0047024 -> 5alpha-androstane-3beta,17beta-diol dehydrogenase activity GO:0008709 -> cholate 7-alpha-dehydrogenase activity

Original comment by: mah11

gocentral commented 13 years ago

Original comment by: mah11