gocentral
commented
13 years ago In line with the cell ontology, added: memory T cell activation ; GO:0035709 CD4-positive, alpha-beta T cell activation ; GO:0035710 T-helper 1 cell activation ; GO:0035711 T-helper 2 cell activation ; GO:0035712
memory T cell = CL:0000813 CD4-positive, alpha-beta T cell = CL:0000624 T-helper 1 cell = CL:0000545 T-helper 2 cell = CL:0000546
All yours for Term Genie for the regulation terms.. I'll change the status to pending till the regulation terms have been added.
thanks, Becky
Original comment by: rebeccafoulger
GO:0042110 T cell activation >> GO new: memory T cell activation
Def: The change in morphology and behavior of a mature memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
GO:0046631 alpha-beta T cell activation >> GO new: CD4-positive alpha-beta T cell activation >>> GO new: T helper 1, CD4-positive alpha-beta T cell activation
Def: The change in morphology and behavior of a mature T helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.
>>> GO new: T helper 2, CD4-positive alpha-beta T cell activation
Def: The change in morphology and behavior of a mature T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. A T-helper 2 cell is a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy.
and pos and neg regulation terms for all :-))
Need pos reg memory T cell activation for P43488 (TNFSF4, OX40L), 12496423, IMP.
cheers
Evelyn
Reported by: evelync
Original Ticket: geneontology/ontology-requests/8213