PRC1-like complex

[gocentral]

A multiprotein complex related to Drosophila PRC1 complex containing the products of many of the Polycomb Group genes. In vertebrates, a family of distinct PRC1-like complexes exist as the products of the various orthologuous genes of Drosphila Pc seem to occur mutually exclusive in respective complexes. The complex is believed to be required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. It acts via chromatin remodeling and modification of histones and mediates monoubiquitination of histone H2A, rendering chromatin heritably changed in its expressibility.

pmid:21282530

Reported by: broechert

Original Ticket: geneontology/ontology-requests/8480

[gocentral]

Not sure if we want altermatively update GO:0035102 PRC1 complex instead (which is Drospophila-centric at the moment). This would be similar then to GO:0035098 ESC/E(Z) complex.

Parent is GO:0031519 PcG protein complex

Original comment by: broechert

[gocentral]

• assigned_to: nobody --> hjdrabkin

Original comment by: rebeccafoulger

[gocentral]

How is difference from PRC1? "An insect multiprotein complex containing the products of many of the Polycomb Group genes..." Actually, all of the children of histone methylase complex may be a bit too specific? also, are the PcG complexes all histone methylases?

Original comment by: hdrabkin

[gocentral]

1 The difference to droso is that droso PRC1 has 4 core subunits and that in vertebrates each of these core subunits has 2 and more orthologs - and there is evidence from studies in mammalia that at least some (e.g. CBX2,4,6 and 7 orthologs of drome Pc occur mutually exclive in complexes and show different nuclear localization - all indicative for distinct PRC1 complexes in vertebrata 2 PcG complexes can be GO:0035097 histone methyltransferase complex like GO:0035098 ESC/E(Z) complex and GO:0000152 nuclear ubiquitin ligase complex as GO:0035102 PRC1 complex (or ...-like) - this relationship is not included in GO - we should do so

3 i would now rather go for a change of current PRC1 definition, like

A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. In Drospphila the core subunits are Pc (Polycomb), Psc (Posterior sex combs), Ph (Polyhomeotic) and Sce (Sex comb extra). In mammals, which have several orthologs for each of the Drosophila core proteins, a family of distinct PRC1-like complexes seem to exist which contain at least some PcG proteins in mutually exclusive manner.

is_a GO:0031519 PcG protein complex GO:0000152 nuclear ubiquitin ligase complex

Original comment by: broechert

[gocentral]

That sounds fine. Harold, do you just want to go ahead and update the definition for GO:0035102 PRC1 complex?

GO Ed

Original comment by: jl242

[gocentral]

• status: open --> pending

Original comment by: jl242

[gocentral]

• status: pending --> closed-accepted

Original comment by: hdrabkin

[gocentral]

Done

Original comment by: hdrabkin