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Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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mitochondrial degradosome #8854

Closed gocentral closed 9 years ago

gocentral commented 13 years ago

Proposal for a new definition:

Ontology Cellular Component

Definition The mitochondrial degradosome (mtEXO) has a 3' to 5' exoribonuclease activity and participates in intron-independent turnover and processing of mitochondrial transcripts. In human it is a pentameric complex consisting of 2 copies of SUPV3L1 and 3 copies of PNPT1. In yeast it is a two-protein complex of Dss1 and Suv3.

PubMed=19509288

Reported by: andrestutz

Original Ticket: geneontology/ontology-requests/8642

gocentral commented 13 years ago

Hi Andre,

Are you suggesting that the definition of the existing term is revised?

currently: mitochondrial degradosome ; GO:0045025 The mitochondrial degradosome (mtEXO) is a three-protein complex which has a 3' to 5' exoribonuclease activity and participates in intron-independent turnover and processing of mitochondrial transcripts. PMID:10397341 PMID:9829834

Becky

Original comment by: rebeccafoulger

gocentral commented 13 years ago

Original comment by: rebeccafoulger

gocentral commented 13 years ago

Yes. See also this paper PMID:12426313 and PMID:17658549 for yeast two-protein complex.

Best regards

Andre

Original comment by: andrestutz

gocentral commented 13 years ago

Hi Andre,

Thanks for the update. I've changed the definition to:

mitochondrial degradosome ; GO:0045025 A mitochondrial complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer

I've avoided putting in protein names, as we are trying to define GO complexes based on their function rather than component, and if we specify components, it gets tricky when homologs in other species aren't named the same etc (we realise most of our GO component definitions don't conform to this ideal). The idea is that PRO will capture the species-specific protein complexes.

Thanks Becky

Original comment by: rebeccafoulger

gocentral commented 13 years ago

Original comment by: rebeccafoulger