EASY: S100 terms needed

[gocentral]

Hi,

Please may I have the following new terms:

as a child of protein biosynthesis: S100 beta biosynthesis S100 alpha biosynthesis

as a child of protein binding: S100 beta binding S100 alpha binding TAU binding

Where S100 is a small calcium & zinc binding protein produced in astrocytes which is NB in Alzheimers, Down Syndrome and ALS.

TAU is a microtubule-associated protein also NB in the same diseases. TAU binds S100.. S100 homodimerizes and heterodimerizes

EV' s REF: P04271 EV ref: P10636

Cheers Evelyn

Reported by: ecamon

Original Ticket: "geneontology/ontology-requests/923":https://sourceforge.net/p/geneontology/ontology-requests/923

[gocentral]

• milestone: --> TermGenie
• assigned_to: nobody --> jenclark

Original comment by: jenclark

[gocentral]

Logged In: YES user_id=735846

planned terms:

New terms:

protein biosynthesis ; GO:0006412 --%S100 beta biosynthesis ; GO:new --%S100 alpha biosynthesis ; GO:new

protein binding ; GO:0005515 --%S100 beta binding ; GO:new --%S100 alpha binding ; GO:new --%tau binding ; GO:new

Definitions:

protein biosynthesis ; GO:0006412 def:The formation from simpler components of a protein, rather than of proteins in general. (already existing)

S100 beta biosynthesis ; GO:new def:The formation from simpler components of S100 beta protein. S100 is a small calcium & zinc binding protein produced in astrocytes that is implicated in Alzheimers, Down Syndrome and ALS.

S100 alpha biosynthesis ; GO:new def:The formation from simpler components of S100 alpha protein. S100 is a small calcium & zinc binding protein produced in astrocytes that is implicated in Alzheimers, Down Syndrome and ALS.

protein binding ; GO:0005515 def:Interacting selectively with any protein, or protein complex (a complex of two or more proteins that may include other nonprotein molecules). (already existing)

S100 beta binding ; GO:new def: Interacting selectively with S100 beta protein. S100 is a small calcium & zinc binding protein produced in astrocytes that is implicated in Alzheimers, Down Syndrome and ALS.

S100 alpha binding ; GO:new def: Interacting selectively with S100 alpha protein. S100 is a small calcium & zinc binding protein produced in astrocytes that is implicated in Alzheimers, Down Syndrome and ALS.

tau binding ; GO:new def: Interacting selectively with TAU protein. tau is a microtubule-associated protein, implicated in Alzheimers, Down Syndrome and ALS.

Original comment by: jenclark

[gocentral]

Logged In: YES user_id=735846

New terms:

protein biosynthesis ; GO:0006412 --%S100 beta biosynthesis ; GO:new GO:0048152 --%S100 alpha biosynthesis ; GO:new GO:0048153

protein binding ; GO:0005515 --%S100 beta binding ; GO:new GO:0048154 --%S100 alpha binding ; GO:new GO:0048155 --%tau binding ; GO:new GO:0048156

Definitions:

protein biosynthesis ; GO:0006412 def:The formation from simpler components of a protein, rather than of proteins in general. (already existing)

S100 beta biosynthesis ; GO:new def:The formation from simpler components of S100 beta protein. S100 is a small calcium & zinc binding protein produced in astrocytes that is implicated in Alzheimers, Down Syndrome and ALS.

S100 alpha biosynthesis ; GO:new def:The formation from simpler components of S100 alpha protein. S100 is a small calcium & zinc binding protein produced in astrocytes that is implicated in Alzheimers, Down Syndrome and ALS.

protein binding ; GO:0005515 def:Interacting selectively with any protein, or protein complex (a complex of two or more proteins that may include other nonprotein molecules). (already existing)

S100 beta binding ; GO:new def: Interacting selectively with S100 beta protein. S100 is a small calcium & zinc binding protein produced in astrocytes that is implicated in Alzheimers, Down Syndrome and ALS.

S100 alpha binding ; GO:new def: Interacting selectively with S100 alpha protein. S100 is a small calcium & zinc binding protein produced in astrocytes that is implicated in Alzheimers, Down Syndrome and ALS.

tau protein binding ; GO:new def: Interacting selectively with tau protein. tau is a microtubule-associated protein, implicated in Alzheimers, Down Syndrome and ALS.

Original comment by: jenclark

[gocentral]

• status: open --> closed-fixed

Original comment by: jenclark