NTR: keratohyalin granule

[gocentral]

def: "irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis, May play a role in keratinization and barrier function"

part_of: CL:0000712 ! stratum granulosum cell

do we need a term basophilic granule? We have mast cell cranule

required to define:

[Term] id: MP:0009602 name: abnormal keratohyalin granule morphology namespace: MPheno.ontology def: "any structural anomaly of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [27thedition\", ISBN:0-683-40008-8\"Stedman's_MedicalDictionary, MGI:csmith\"Cynthia_L._Smith, Mouse_Genome_Informatics_Curator\"] synonym: "abnormal keratohyaline granule morphology" EXACT [] is_a: MP:0001239 ! abnormal epidermis stratum granulosum morphology

Reported by: cmungall

Original Ticket: geneontology/ontology-requests/8998

[gocentral]

• assigned_to: nobody --> rfoulger

Original comment by: rebeccafoulger

[gocentral]

The current definition of mast cell granule allows for localization in basophil cells:

mast cell granule ; GO:0042629 Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase.

So not sure a 'basophilic granule' is a good term, unless there's something special about the granules in a basophil cell. I'll add in specific term for 'keratohyalin granule' tho.

Becky

Original comment by: rebeccafoulger

[gocentral]

New term added: keratohyalin granule ; GO:0036045

Becky

Original comment by: rebeccafoulger

[gocentral]

• status: open --> closed-accepted

Original comment by: rebeccafoulger