yeast cell germ tube growth

[gocentral]

NT: yeast cell germ tube growth

Possible Definition: Development of slender tubular outgrowth first produced by cells yeast cells undergoing a yeast-to-hypha transition following exposure to filament-inducing conditions. Example of this process are found in Candida albicans and other systemic dimorphic fungi.

Synonyms: yeast cell germination, germ tube formation, germ tube development, yeast to hyphal transition, hyphal morphogenesis, hypha formation, blastoconidia germination

Alternatively, this term could be made more generic and would apply to spores and yeast cells undergoing germ tube formation: "germ tube formation" Definition: Development of slender tubular outgrowth first produced by cells following exposure to filament-inducing conditions. Another alternative term: germ tube growth or formation

Possible child of developmental process/ (GO:0032502)

Possible sibling of spore germination/Process (GO:0009847

Note that yeast cells are referred to extensively in the literature as forming germ tubes in response to certain environmental stimuli. Since yeast cells are completely distinct from spores, yeast cells need their own term. In addition to C. albicans, thermally dimorphic fungi also produce yeast cells which form germ tubes at ambient temperature. For review on germ tube growth of C. albicans see PMID: 9504066, PMID: 7035580, PMID: 3278238, PMID: 9884022, PMID: 21926199.

Reported by: dinglis

Original Ticket: geneontology/ontology-requests/9331

[gocentral]

Hi Diane,

Is there another way the yeast and spore germ tubes can be distinguished? We wouldn't want to include 'yeast' in the term name.

Thanks, Becky

Original comment by: rebeccafoulger

[gocentral]

Hi Becky,

Yeast germ tubes are visually indistinguishable from spore germ tubes which is probably why they were originally called "germ tubes" or "germination tubes" even though germination is usually a process that involves spores and seeds (dormant cells), not vegetative cells. The cell-type that produces the germ tube is the major difference in this case.

I need a term for the process of process of a yeast cell making a filamentous cell, the actual transition, for annotating mutants that can't form filaments from yeast when examined as individual cells. I think the problem may be with the confusing application of the word "germ tube" to C. albicans growth. By the GO definition, germ tubes are made by spores ("The slender tubular outgrowth first produced by most spores in germination."). I also realized that I should avoid children of "developmental process."

What about "cell growth mode switching, budding to filamentous" similar to GO:0051524? Child of "regulation of direction of cell growth" GO:0061389

Thank you,

Diane

Original comment by: dinglis

[gocentral]

Hi Becky,

Here's a possible definition that might work.

"cell growth mode switching, budding to filamentous" "The production of filamentous cells, or cells growing in a threadlike, filamentous shape, from budding cells in a population of unicellular organisms. An example of this is the yeast-hyphal transition of Candida albicans."

Diane

Original comment by: dinglis

[gocentral]

• assigned_to: nobody --> rfoulger

Original comment by: jl242

[gocentral]

Ok... added:

[Term] id: GO:0036187 name: cell growth mode switching, budding to filamentous namespace: biological_process def: "The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans." [GOC:di] synonym: "yeast to hyphal transition" RELATED [GOC:di] is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells created_by: rfoulger creation_date: 2012-04-18T11:32:57Z

Original comment by: rebeccafoulger

[gocentral]

• status: open --> closed-accepted

Original comment by: rebeccafoulger