cell morphogenesis involved in phenotypic switching

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NT: cell morphogenesis involved in phenotypic switching

Hello there,

C. albicans and other non-yeast species, such as bacteria) undergo a process called "phenotypic switching."This reversible transition involves changes in cell shape, permeability, and colony morphology. I need a term to describe the process of phenotypic switching. For references see PMID: 3284370, 1576587, 2157666 to name just a few.

Possible Parent: (GO:0000902) cell morphogenesis, other suggestions welcome.

Thank you,

Diane

Reported by: dinglis

Original Ticket: geneontology/ontology-requests/9337

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• assigned_to: nobody --> rfoulger

Original comment by: rebeccafoulger

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Added two terms in:

phenotypic switching ; GO:0036166 phenotypic switching in response to host ; GO:0036167

to allow for phenotype switching in mutli-cellular organisms (eg smooth muscle cells: PMID: 22406749).

Is mating type switching ; GO:0007533 considered a type of phenotypic switching? If so, I'll create a relationship between the terms.

Also, you can go ahead tomorrow and use TermGenie to create the 'involved _in' term you requested. Let me know if you're not set up on TG and I'll email you a guide.

Thanks, Becky

Original comment by: rebeccafoulger

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• status: open --> pending

Original comment by: rebeccafoulger

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> Is mating type switching ; GO:0007533 considered a type of phenotypic > switching?

I wouldn't call this a definitive answer, but ...

I'm somewhat inclined to think not, partly because I've never heard it so described, but more because mating type switching doesn't just refer to the phenotype of which mating type a cell acts as. The main process of mating type switching is the molecular events that result in swapping out the DNA sequences at one actively expressed locus using the sequence at one or the other of two silenced loci. The phenotypic changes are consequences of the DNA changes, but "mating type switching" really refers primarily to the DNA recombination.

Does that make sense? m

Original comment by: mah11

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Hi Becky,

I agree with Midori. Phenotypic switching is the result of regulation of white or opaque phase gene expression via a transcriptional regulatory network whereas mating type switching refers to the molecular events that occur at the level of DNA recombination. So mating type switching should not be considered a type of phenotypic switching.

Diane

Original comment by: dinglis

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• status: pending --> open

Original comment by: dinglis

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Ok- thanks for the explanations. I'll leave 'phenotypic switching' and 'mating type switching' separate.

All yours for TermGenie Diane, for the involved_in term.

Thanks, Becky

Original comment by: rebeccafoulger

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• status: open --> pending-accepted

Original comment by: rebeccafoulger

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Diane has created a TG term, so I'm closing this SF. regulation of cell morphogenesis involved in phenotypic switching ; GO:1900447

Original comment by: rebeccafoulger

[gocentral]

• status: pending-accepted --> closed-accepted

Original comment by: rebeccafoulger