Closed gocentral closed 9 years ago
Hi Becky,
Could you please look into this receptor-related request - If not, please assign to myself.
Thanks, Paola
Original comment by: paolaroncaglia
Original comment by: paolaroncaglia
Hi Anna Maria,
We try to make specific terms like this only when the internalization affects the signaling pathway (or other process): e.g. see the children of insulin receptor internalization ; GO:0038016 & Wnt receptor internalization ; GO:0038017. Does the BCR internalization have a positive or negative effect on the signaling pathway? (in which case I'll create a more specific term). If not, I'd suggest annotating to 'receptor internalization ; GO:0031623' and capture the ID of the BCR at the annotation extension stage.
Thanks, Becky
Original comment by: rebeccafoulger
Hi Becky, BCR internalizationaffect mainly the antigen processing and presentation but , also affect negatively: the BCR signaling because crosslinked BCRs are ultimately degraded following their uptake positively: can affect the TLR7 and TLR9 signaling by transfer DNA /RNA antigen to those receptors. Please let me know if these are things that would make reasonable have a specific term for BCR. Thanks AM
Original comment by: masciam
Hi, Thanks for the info.. do you have any papers/reviews I can take a look at for those processes? cheers, Becky
Original comment by: rebeccafoulger
Here are the PMIDs that I have available let me know if you need more PMID: 18513998 PMID: 10996020 AM
Original comment by: masciam
I certainly think this is a worthy term to add to the GO as BCR internalization is both a well-studied and important process for the functioning of the immune system.
-- Alex
Original comment by: addiehl
Added: B cell receptor internalization ; GO:0036300
Will add a signaling term via TG1: positive regulation of TLR9 signaling by B cell receptor internalization ; GO:NEW (PMID:18513998)
We already have a related term for the related antigen processing: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen ; GO:0002417 I haven't given GO:0002417 a link to the new term because the parentage suggests that receptor internalization is first and THEN the processing occurs.
Thanks for the papers Anna. Becky
Original comment by: rebeccafoulger
Submitted via TG1:
GO:1901245 Label: positive regulation of toll-like receptor 9 signaling pathway by B cell receptor internalization
Original comment by: rebeccafoulger
Original comment by: rebeccafoulger
Thanks Becky
Original comment by: masciam
Original comment by: masciam
Original comment by: rebeccafoulger
A receptor-mediated endocytosis process that results in the movement of a B cell receptor from the plasma membrane to the inside of the cell.
Reported by: masciam
Original Ticket: geneontology/ontology-requests/9640