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Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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dense granule (GO:0020026) #991

Closed gocentral closed 9 years ago

gocentral commented 21 years ago

Hi,

Would it be possible to widen the definition of the function term: dense granule (GO:0020026), to include those present within platelets?

Platelet dense granules are secretory granules and contribute in the formation of the hemostatic plug.
They contain a highly condensed core consisting of serotonin, calcium, ATP, ADP, pyrophosphate and membrane lysosomal proteins.

(literature references: pubmed 10403682, 10877819)

Thanks,

Emily

(For annotation of Q9NQG7)

Reported by: edimmer

Original Ticket: "geneontology/ontology-requests/994":https://sourceforge.net/p/geneontology/ontology-requests/994

gocentral commented 21 years ago

Original comment by: jl242

gocentral commented 21 years ago

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I think that parasite dense granules are probably quite different to platelet dense granules, so I'll think this will need a new term - maybe with sensu qualifiers. Will look into it.

Original comment by: jl242

gocentral commented 21 years ago

Original comment by: jl242

gocentral commented 21 years ago

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I agree with Jane; methinks platelet dense granules are a type of secretory granule, but 20026 is there to accommodate the bizarre biology of apicomplexans.

See if secretory granule (GO:0030141) will do; if so, add 'dense granule' as a synonym (not sure whether exact or not off the top of my head). If a disticnt term is called for, add 'platelet dense granule.' In either case, add a sensu designation to 20026.

m

Original comment by: mah11

gocentral commented 21 years ago

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Okay, what I'll do is change 'dense granule ; GO:0020026' to 'dense granule (sensu Apicomplexa) ; GO:0020026' and add a new term 'platelet dense granule ; GO:new' under 'secretory granule' (synonym: secretory vesicle).

Matt - it sounds like 'dense granule (sensu Apicomplexa) ; GO:0020026' should be moved from where it is now, under 'secretory granule'. How about under 'cytoplasmic vesicle' or just 'cytoplasm'?

Original comment by: jl242

gocentral commented 21 years ago

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under 'cytoplasmic vesicle' sounds like a cunning plan.

matt

Original comment by: mberriman

gocentral commented 21 years ago

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Okay, added 'platelet dense granule ; GO:0042827' under 'secretory granule'. Moved and changed name of 'dense granule ; GO:0020026' as described below.

Original comment by: jl242

gocentral commented 21 years ago

Original comment by: jl242