Closed nathandunn closed 2 years ago
FYI @lpalbou
Hi @nathandunn,
We're collecting use cases for Slims, so I will add this to the list.
I'm working with Tom H on aligning PW to GO. This is a category of slim that could be autogenerated based on presence/absence of a mapping.
reaction slim: Rhea (better than EC as Rhea gives level of specificity) pathway slim: PW or Reactome (PW may be better for a pathway via as Reactome maps to different levels in GO) or metacyc (but metacyc mappings are very incomplete)
@cmungall to be able to push the autogenerated slims to our tool would be a nice feature
FYI @lpalbou @jingchunzhu
@cmungall turns out Suzi created a GO slim for the Xena Widget / TCGA data: https://github.com/ucscXena/XenaGoWidget/blob/develop/src/data/genesets/tgac.js
The gene sets are obsolete (2y+) but the slim set could be valid. Who would be our expert in GO to ask for more feedback ? It would be great if this could be an official GO slim for cancer.
I'm not sure what you want in a GO slim for cancer. A good slim covering human should do this job as cancer is not restricted to a small subset of genes or processes (covers cytoskeletal processes, DNA. metabolism, gene expression, mRNA metabolism, cell cycle control, vesicle-mediated transport, telomeric processes etc. etc.) If you can provide more details about what you need in a "cancer slim", we can see how well the new generic slim covering human fits (you are likely to need a subset of this). However, it's a moving target as annotations to cancer-causing genes become extended (i.e there are very few cell level processes that are not implicated in cancers, so maybe what you need is a good cell-level slim?)
@RLovering @pgaudet
@nathandunn we are doing a Slim workshop at this GOC meeting this week, scheduled for Thursday's second session. Let me know if you or your group would like to attend and I can send Zoom/agenda info.
Hello,
Our group is trying to find more a GO slim that can be used to find pathways for cancer tumor cells in humans.
https://xenabrowser.net/ / https://github.com/ucscXena/XenaGoWidget/
I haven't seen anything explicit, but maybe you could point me in the right direction.
Cross-reference here: https://github.com/ucscXena/XenaGoWidget/issues/604
Thanks,
Nathan