Gtr1 (RagA GTPase Gtr1)
enables protein serine/threonine kinase activator activity
part_of positive regulation of TORC1 signaling
Tor2 (TORC1 serine/threonine protein kinase)
protein serine/threonine kinase activity
part_of TORC1 signaling (GO:0038202)
occurs_in fungal-type vacuole membrane (GO:0000329)
I will then connect them up as:
Npr3 has_input (relation: directly negatively regulates) Gtr1
Gtr1 has_input (relation: directly positively regulates) Tor2
However, if I add the Npr3 annotation, and then try to create the Gtr1 annotation, the BP for Gtr1 gets switched to negative regulation of TORC1 signaling. If I then do it the other way around the Npr3 annotation gets switched to positive regulation. (even though I explicitly stated the opposite in the annoton).
What am I doing wrong?
Could this be trouble-shooted on the Next Noctua office hours call? (or some other time).
http://noctua.berkeleybop.org/editor/graph/gomodel:60e7989d00000085)
I am trying to create a model with the following 3 annotons:
Npr3 (GATOR1-SEACIT GTPase complex subunit Npr3) enables GTPase activator activity part_of negative regulation of TORC1 signaling occurs_during cellular response to nitrogen starvation
Gtr1 (RagA GTPase Gtr1) enables protein serine/threonine kinase activator activity part_of positive regulation of TORC1 signaling
Tor2 (TORC1 serine/threonine protein kinase) protein serine/threonine kinase activity part_of TORC1 signaling (GO:0038202) occurs_in fungal-type vacuole membrane (GO:0000329)
I will then connect them up as: Npr3 has_input (relation: directly negatively regulates) Gtr1 Gtr1 has_input (relation: directly positively regulates) Tor2
However, if I add the Npr3 annotation, and then try to create the Gtr1 annotation, the BP for Gtr1 gets switched to negative regulation of TORC1 signaling. If I then do it the other way around the Npr3 annotation gets switched to positive regulation. (even though I explicitly stated the opposite in the annoton).
What am I doing wrong? Could this be trouble-shooted on the Next Noctua office hours call? (or some other time).
Thanks