geneontology / noctua

Graph-based modeling environment for biology, including prototype editor and services
http://noctua.geneontology.org/
BSD 3-Clause "New" or "Revised" License
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Queries to assess use of MF-to-BP relations in Noctua models #827

Open vanaukenk opened 1 year ago

vanaukenk commented 1 year ago

We are working on annotation documentation for MF-to-BP relations and would like to assess the extent to which relations, other than 'part of', have been used to link MFs to BPs in Noctua.

We would like to exclude the whole genome import models, since we know that these models used 'causally upstream of or within' (or perhaps a child) and we're not concerned with those right now.

Here are two possible queries we can think of to try to find use of these relations (i.e. not 'part of') in other models:

  1. Using existing definition of GO-CAM (three successive MFs linked by two causal relations), check to see if any of those models also include an MF to BP with a causally upstream of or within relation (or child, i.e. positive, negative effect)

  2. Look for any model where exists a non-root MF linked to a BP with a causally upstream of or within relation (or child, i.e. positive, negative effect)

@balhoff @ukemi @pgaudet @vanaukenk

kltm commented 1 year ago

"Internal" endpoint including dev models: http://rdf-internal.berkeleybop.io/

balhoff commented 1 year ago

Here is a query that gives 440 edges. It takes about 40 seconds (so it almost times out with our current settings):

PREFIX owl: <http://www.w3.org/2002/07/owl#>
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>
PREFIX bds: <http://www.bigdata.com/rdf/search#>
PREFIX part_of: <http://purl.obolibrary.org/obo/BFO_0000050>
PREFIX BP: <http://purl.obolibrary.org/obo/GO_0008150>
PREFIX MF: <http://purl.obolibrary.org/obo/GO_0003674>
PREFIX CC: <http://purl.obolibrary.org/obo/GO_0005575>

SELECT DISTINCT ?cam (STR(?mf_label) AS ?mf_name) (STR(?rel_label) AS ?rel_name) (STR(?bp_label) AS ?bp_name)
WHERE {
  ?bp rdf:type BP: .
  ?mf rdf:type MF: .
  ?rel a owl:ObjectProperty .
  # This pattern selects asserted GO-CAM graphs
  ?cam <http://geneontology.org/lego/modelstate> ?state .
  GRAPH ?cam {
    ?mf ?rel ?bp .
  }
  GRAPH ?cam {
    ?mf rdf:type ?asserted_mf_type .
    FILTER(?asserted_mf_type != MF:)
    FILTER(?asserted_mf_type != owl:NamedIndividual)
  }
  GRAPH ?cam {
    ?bp rdf:type ?asserted_bp_type .
    FILTER(?asserted_bp_type != owl:NamedIndividual)
  }
  ?asserted_mf_type rdfs:subClassOf MF: .
  ?asserted_bp_type rdfs:subClassOf BP: .
  ?asserted_mf_type rdfs:label ?mf_label .
  ?asserted_bp_type rdfs:label ?bp_label .
  ?rel rdfs:label ?rel_label .
  FILTER(?rel != part_of:)
  FILTER(isIRI(?mf))
  FILTER(isIRI(?bp))
}
#LIMIT 1000
balhoff commented 1 year ago
Table of 440 results |cam |mf_name |rel_name |bp_name | |----------------------------------------------|--------------------------------------------------------------------------------------------------------------------|-----------------------------------------------|----------------------------------------------------------------------------------------------------------------| |http://model.geneontology.org/568b0f9600000024|DNA-binding transcription repressor activity, RNA polymerase II-specific |negatively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/5666dc6c00000018|DNA-binding transcription repressor activity, RNA polymerase II-specific |positively regulates |dauer entry | |http://model.geneontology.org/5666dc6c00000558|single-stranded DNA endodeoxyribonuclease activity |positively regulates |double-strand break repair via homologous recombination | |http://model.geneontology.org/57c82fad00000284|phosphatidylinositol phospholipase C activity |positively regulates |neuropeptide secretion from presynapse | |http://model.geneontology.org/5745387b00001247|acetylcholinesterase activity |negatively regulates |memory | |http://model.geneontology.org/5745387b00001247|acetylcholinesterase activity |negatively regulates |synaptic transmission, cholinergic | |http://model.geneontology.org/5a7e68a100001868|G protein-coupled adenosine receptor activity |causally upstream of, positive effect |D-aspartate import across plasma membrane | |http://model.geneontology.org/5fadbcf000001493|G protein-coupled chemoattractant receptor activity |negatively regulates |regulation of DNA-binding transcription factor activity | |http://model.geneontology.org/5fadbcf000000208|DNA-binding transcription activator activity, RNA polymerase II-specific |positively regulates |negative regulation of cyclin-dependent protein kinase activity | |http://model.geneontology.org/542732ad00000005|nitric-oxide synthase activity |positively regulates |adrenergic receptor signaling pathway | |http://model.geneontology.org/5b528b1100000489|RNA polymerase II transcription regulatory region sequence-specific DNA binding |positively regulates |IRE1-mediated unfolded protein response | |http://model.geneontology.org/57ea2dae00000114|RNA polymerase II transcription regulatory region sequence-specific DNA binding |positively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/5900dc7400000172|RNA polymerase II transcription regulatory region sequence-specific DNA binding |directly activates |positive regulation of transcription by RNA polymerase II | |http://model.geneontology.org/595a9ee700000584|RNA polymerase II transcription regulatory region sequence-specific DNA binding |causally upstream of or within |cell migration | |http://model.geneontology.org/600ced8500001866|SNARE binding |enables |SNARE complex assembly | |http://model.geneontology.org/59bee34700000000|adenylate cyclase activity |directly provides input for |cAMP-mediated signaling | |http://model.geneontology.org/593423e000000174|deoxyribonuclease I activity |causally upstream of, positive effect |execution phase of apoptosis | |http://model.geneontology.org/5716c41300000127|fatty acid synthase activity |causally upstream of or within |tissue development | |http://model.geneontology.org/5716c41300000127|fatty acid synthase activity |causally upstream of or within |establishment of endothelial intestinal barrier | |http://model.geneontology.org/5716c41300000127|fatty acid synthase activity |causally upstream of or within |cell development | |http://model.geneontology.org/57f1b14b00000442|phosphoethanolamine N-methyltransferase activity |causally upstream of or within |multicellular organism reproduction | |http://model.geneontology.org/5745387b00001977|GTPase activity |positively regulates |phagosome-lysosome fusion | |http://model.geneontology.org/5745387b00001977|GTPase activity |positively regulates |phagosome maturation | |http://model.geneontology.org/5745387b00001977|GTPase activity |positively regulates |defense response to Gram-positive bacterium | |http://model.geneontology.org/56d1143000000029|rDNA binding |positively regulates |transcription by RNA polymerase I | |http://model.geneontology.org/55dce5d200000074|GTPase activity |regulates |leaf development | |http://model.geneontology.org/5667fdd400000315|GTPase activity |positively regulates |protein localization to plasma membrane | |http://model.geneontology.org/5525a0fc00000061|GTPase activity |directly inhibits |exit from mitosis | |http://model.geneontology.org/56aac7ad00000175|GTPase activity |positively regulates |actin filament polymerization | |http://model.geneontology.org/62183af000000000|binding |happens during |mitotic anaphase A | |http://model.geneontology.org/5d29221b00001310|GTPase activity |positively regulates |hormone secretion | |http://model.geneontology.org/5d29221b00001310|GTPase activity |causally upstream of, positive effect |hormone secretion | |http://model.geneontology.org/5d29221b00001310|GTPase activity |causally upstream of or within, positive effect|hormone secretion | |http://model.geneontology.org/5a7e68a100000920|GTPase activity |causally upstream of, negative effect |pheromone-dependent signal transduction involved in conjugation with cellular fusion | |http://model.geneontology.org/5b528b1100001112|GTPase activity |causally upstream of, positive effect |establishment of mitotic spindle localization | |http://model.geneontology.org/5ae3b0f600001186|general transcription initiation factor activity |causally upstream of or within |vasculogenesis | |http://model.geneontology.org/5d29221b00002414|RNA polymerase II cis-regulatory region sequence-specific DNA binding |causally upstream of or within |B cell differentiation | |http://model.geneontology.org/5900dc7400000539|RNA polymerase II cis-regulatory region sequence-specific DNA binding |positively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/5900dc7400000409|RNA polymerase II cis-regulatory region sequence-specific DNA binding |positively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/59cde02c00000053|catalytic activity |regulates |lipid biosynthetic process | |http://model.geneontology.org/59cde02c00000053|catalytic activity |regulates |cinnamic acid biosynthetic process | |http://model.geneontology.org/5e72450500000646|ATP-activated inward rectifier potassium channel activity |causally upstream of or within |regulation of heart contraction | |http://model.geneontology.org/5e72450500002742|molecular adaptor activity |positively regulates |membrane fission | |http://model.geneontology.org/5e72450500002742|molecular adaptor activity |transports or maintains localization of |membrane fission | |http://model.geneontology.org/5e72450500003254|molecular adaptor activity |positively regulates |receptor internalization | |http://model.geneontology.org/5e72450500003254|molecular adaptor activity |positively regulates |membrane fission | |http://model.geneontology.org/5e72450500002742|molecular adaptor activity |positively regulates |clathrin coat assembly | |http://model.geneontology.org/581e072c00000182|molecular adaptor activity |positively regulates |DNA damage checkpoint signaling | |http://model.geneontology.org/5b528b1100002161|glucose-6-phosphate dehydrogenase activity |causally upstream of |sex differentiation | |http://model.geneontology.org/5900dc7400001128|plus-end-directed microtubule motor activity |causally upstream of or within |cell migration | |http://model.geneontology.org/59cde02c00000102|glycosaminoglycan binding |directly positively regulates |amyloid precursor protein catabolic process | |http://model.geneontology.org/5e72450500004237|fusogenic activity |causally upstream of |viral translation | |http://model.geneontology.org/593423e000001059|DNA-binding transcription factor activity, RNA polymerase II-specific |causally upstream of or within, positive effect|melanocyte differentiation | |http://model.geneontology.org/5900dc7400000941|DNA-binding transcription factor activity, RNA polymerase II-specific |directly activates |transcription by RNA polymerase II | |http://model.geneontology.org/600ced8500002128|mitochondrial transcription factor activity |happens during |G2 phase | |http://model.geneontology.org/600ced8500002128|mitochondrial transcription factor activity |happens during |M phase | |http://model.geneontology.org/5835403200000017|DNA-binding transcription factor activity, RNA polymerase II-specific |positively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/5825564b00000062|DNA-binding transcription factor activity, RNA polymerase II-specific |directly activates |transcription by RNA polymerase II | |http://model.geneontology.org/5745387b00000404|DNA-binding transcription factor activity, RNA polymerase II-specific |positively regulates |mRNA transcription by RNA polymerase II | |http://model.geneontology.org/57c4867e00000208|DNA-binding transcription factor activity, RNA polymerase II-specific |directly activates |transcription by RNA polymerase II | |http://model.geneontology.org/5482537600000031|DNA-binding transcription factor activity, RNA polymerase II-specific |directly inhibits |transcription by RNA polymerase II | |http://model.geneontology.org/567b544200000029|DNA-binding transcription factor activity, RNA polymerase II-specific |directly activates |transcription by RNA polymerase II | |http://model.geneontology.org/5fce9b7300000451|apelin receptor binding |causally upstream of, positive effect |Kupffer's vesicle development | |http://model.geneontology.org/56d1143000000436|DNA-binding transcription factor activity, RNA polymerase II-specific |directly activates |transcription by RNA polymerase II | |http://model.geneontology.org/5ee8120100002841|signaling receptor activity |causally upstream of or within, positive effect|NIK/NF-kappaB signaling | |http://model.geneontology.org/5716c41300000192|potassium:chloride symporter activity |causally upstream of |microvillus organization | |http://model.geneontology.org/5b528b1100002019|transporter activity |happens during |M phase | |http://model.geneontology.org/5ae3b0f600000435|signaling receptor activity |causally upstream of or within |ERK1 and ERK2 cascade | |http://model.geneontology.org/5ae3b0f600000435|signaling receptor activity |causally upstream of or within |phosphatidylinositol 3-kinase signaling | |http://model.geneontology.org/5b528b1100001803|DNA-binding transcription factor activity, RNA polymerase II-specific |causally upstream of or within, positive effect|transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification | |http://model.geneontology.org/5b528b1100001803|DNA-binding transcription factor activity, RNA polymerase II-specific |causally upstream of or within, positive effect|transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification | |http://model.geneontology.org/5b318d0900001027|DNA-binding transcription factor activity, RNA polymerase II-specific |causally upstream of, positive effect |nodal signaling pathway | |http://model.geneontology.org/5c4605cc00001646|DNA-binding transcription factor activity, RNA polymerase II-specific |causally upstream of or within |lymphangiogenesis | |http://model.geneontology.org/5c4605cc00001646|DNA-binding transcription factor activity, RNA polymerase II-specific |causally upstream of or within, positive effect|lymphangiogenesis | |http://model.geneontology.org/5b91dbd100002183|DNA-binding transcription factor activity, RNA polymerase II-specific |causally upstream of or within |compound eye photoreceptor cell differentiation | |http://model.geneontology.org/5b91dbd100002145|DNA-binding transcription factor activity, RNA polymerase II-specific |causally upstream of or within |myoblast maturation | |http://model.geneontology.org/5e72450500002719|DNA-binding transcription activator activity |positively regulates |mRNA transcription | |http://model.geneontology.org/5a7e68a100000920|ABC-type peptide transporter activity |causally upstream of or within |peptide pheromone export | |http://model.geneontology.org/5e72450500002742|protein kinase activity |negatively regulates |protein targeting | |http://model.geneontology.org/5e72450500002742|protein kinase activity |positively regulates |clathrin coat assembly | |http://model.geneontology.org/5b91dbd100001639|apolipoprotein A-I binding |happens during |M phase | |http://model.geneontology.org/5f46c3b700003182|protein kinase activity |causally upstream of or within |regulation of pseudopodium assembly | |http://model.geneontology.org/5ee8120100001716|protein kinase activity |causally upstream of or within |protein localization to nucleus | |http://model.geneontology.org/5ae3b0f600001114|protein kinase activity |directly positively regulates |proteasomal protein catabolic process | |http://model.geneontology.org/57c4867e00000233|protein kinase activity |causally upstream of |peptidyl-threonine phosphorylation | |http://model.geneontology.org/5ae3b0f600001522|protein kinase activity |causally upstream of, positive effect |canonical Wnt signaling pathway | |http://model.geneontology.org/5d29221b00000131|beta-catenin binding |negatively regulates |canonical Wnt signaling pathway | |http://model.geneontology.org/56d1143000003025|protein kinase activity |positively regulates |proteasomal protein catabolic process | |http://model.geneontology.org/580685bd00000194|protein kinase activity |happens during |male meiotic nuclear division | |http://model.geneontology.org/580fe05a00000006|protein kinase activity |regulates |cytoskeleton organization | |http://model.geneontology.org/5966411600000538|protein kinase activity |positively regulates |proteasomal protein catabolic process | |http://model.geneontology.org/584718ce00000023|protein kinase activity |directly provides input for |protein dephosphorylation | |http://model.geneontology.org/584718ce00000023|protein kinase activity |directly provides input for |protein phosphorylation | |http://model.geneontology.org/60ad85f700002009|phosphoric diester hydrolase activity |causally upstream of or within, negative effect|protein ADP-ribosylation | |http://model.geneontology.org/60ad85f700002009|phosphoric diester hydrolase activity |causally upstream of or within, negative effect|protein mono-ADP-ribosylation | |http://model.geneontology.org/60ad85f700002009|phosphoric diester hydrolase activity |causally upstream of or within, negative effect|protein poly-ADP-ribosylation | |http://model.geneontology.org/5e72450500004237|translation activator activity |directly positively regulates |viral translation | |http://model.geneontology.org/5c4605cc00003572|[heparan sulfate]-glucosamine N-sulfotransferase activity |causally upstream of or within |heparan sulfate proteoglycan biosynthetic process | |http://model.geneontology.org/595a9ee700000584|Wnt-protein binding |causally upstream of, positive effect |transcription by RNA polymerase II | |http://model.geneontology.org/595a9ee700000584|Wnt-protein binding |causally upstream of or within |cell migration | |http://model.geneontology.org/59dc728000000510|receptor ligand activity |regulates |transport | |http://model.geneontology.org/57c4867e00000002|receptor ligand activity |positively regulates |presynaptic active zone assembly | |http://model.geneontology.org/5fce9b7300000451|apelin receptor activity |causally upstream of or within, positive effect|determination of heart left/right asymmetry | |http://model.geneontology.org/5fce9b7300000451|apelin receptor activity |causally upstream of or within, positive effect|determination of liver left/right asymmetry | |http://model.geneontology.org/5fce9b7300000451|apelin receptor activity |causally upstream of, positive effect |Kupffer's vesicle development | |http://model.geneontology.org/57f1b14b00000466|GDP binding |directly activates |heterotrimeric G-protein complex assembly | |http://model.geneontology.org/56aac7ad00000175|cytoskeletal anchor activity |positively regulates |actin filament polymerization | |http://model.geneontology.org/57f1b14b00000492|ubiquitin-like protein conjugating enzyme activity |immediately causally upstream of |protein lipidation | |http://model.geneontology.org/586fc17a00000338|molecular function regulator activity |positively regulates |actin filament-based movement | |http://model.geneontology.org/617b481400002264|RNA adenylyltransferase activity |has input |RNA polyadenylation | |http://model.geneontology.org/5c4605cc00003975|NADH dehydrogenase (ubiquinone) activity |causally upstream of or within |regulation of mitochondrial membrane potential | |http://model.geneontology.org/5c4605cc00003949|NADH dehydrogenase (ubiquinone) activity |causally upstream of or within |response to injury involved in regulation of muscle adaptation | |http://model.geneontology.org/5c4605cc00003949|NADH dehydrogenase (ubiquinone) activity |causally upstream of or within |reactive oxygen species metabolic process | |http://model.geneontology.org/5fce9b7300000451|receptor ligand activity |causally upstream of or within, positive effect|determination of liver left/right asymmetry | |http://model.geneontology.org/5fce9b7300000451|receptor ligand activity |causally upstream of or within, positive effect|determination of heart left/right asymmetry | |http://model.geneontology.org/5d29221b00002678|receptor ligand activity |negatively regulates |neuron death in response to oxidative stress | |http://model.geneontology.org/5f421e9000000034|receptor ligand activity |causally upstream of or within, positive effect|cell migration | |http://model.geneontology.org/5f421e9000000034|receptor ligand activity |causally upstream of or within, positive effect|metanephros development | |http://model.geneontology.org/5f421e9000000034|receptor ligand activity |causally upstream of or within, positive effect|metanephric tubule development | |http://model.geneontology.org/5f46c3b700002829|phosphatidylinositol phosphate binding |causally upstream of or within |actin filament polymerization | |http://model.geneontology.org/617b481400002223|ubiquitin protein ligase activity |causally upstream of |positive regulation of NF-kappaB transcription factor activity | |http://model.geneontology.org/617b481400002223|ubiquitin protein ligase activity |directly negatively regulates |viral genome replication | |http://model.geneontology.org/57ea2dae00000012|peptidase activity |negatively regulates |blood coagulation | |http://model.geneontology.org/5ee8120100001217|ubiquitin protein ligase activity |causally upstream of or within |anterior/posterior pattern specification | |http://model.geneontology.org/5e72450500002742|ubiquitin protein ligase activity |negatively regulates |membrane fission | |http://model.geneontology.org/5e72450500002742|ubiquitin protein ligase activity |positively regulates |protein targeting | |http://model.geneontology.org/5ee8120100001217|ubiquitin protein ligase activity |causally upstream of or within |negative regulation of Wnt signaling pathway | |http://model.geneontology.org/5745387b00000350|ubiquitin protein ligase activity |participates in |negative regulation of signal transduction by p53 class mediator | |http://model.geneontology.org/5745387b00000350|ubiquitin protein ligase activity |participates in |negative regulation of signal transduction by p53 class mediator | |http://model.geneontology.org/5745387b00000350|ubiquitin protein ligase activity |participates_in |negative regulation of signal transduction by p53 class mediator | |http://model.geneontology.org/5b91dbd100001682|ubiquitin protein ligase activity |causally upstream of or within |NIK/NF-kappaB signaling | |http://model.geneontology.org/5666dc6c00000558|ubiquitin protein ligase activity |positively regulates |double-strand break repair via homologous recombination | |http://model.geneontology.org/586fc17a00000280|ubiquitin protein ligase activity |positively regulates |ubiquitin-dependent protein catabolic process | |http://model.geneontology.org/581e072c00000123|ubiquitin protein ligase activity |positively regulates |ubiquitin-dependent protein catabolic process | |http://model.geneontology.org/5e72450500003254|clathrin binding |positively regulates |receptor internalization | |http://model.geneontology.org/5e72450500002742|clathrin binding |positively regulates |clathrin coat assembly | |http://model.geneontology.org/617b481400000153|chromatin binding |happens during |mitotic M phase | |http://model.geneontology.org/617b481400000153|chromatin binding |happens during |mitotic G1 phase | |http://model.geneontology.org/57c4867e00000233|protein kinase activator activity |positively regulates |peptidyl-threonine phosphorylation | |http://model.geneontology.org/5667fdd400000141|chromatin binding |negatively regulates |mitotic sister chromatid segregation | |http://model.geneontology.org/5f46c3b700001629|single-stranded DNA binding |causally upstream of or within |positive regulation of transcription by RNA polymerase II | |http://model.geneontology.org/5900dc7400001128|receptor tyrosine kinase binding |causally upstream of or within |cell migration | |http://model.geneontology.org/5900dc7400001128|receptor tyrosine kinase binding |positively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/61e0e55600001095|RNA helicase activity |causally upstream of or within |post-transcriptional regulation of gene expression | |http://model.geneontology.org/5b528b1100001061|RNA helicase activity |causally upstream of |protein folding | |http://model.geneontology.org/5f46c3b700002608|protein kinase inhibitor activity |happens during |meiotic cell cycle phase | |http://model.geneontology.org/59c8885900000374|protein kinase inhibitor activity |negatively regulates |receptor signaling pathway via JAK-STAT | |http://model.geneontology.org/5a7e68a100000920|cyclin-dependent protein serine/threonine kinase inhibitor activity |causally upstream of, negative effect |cell cycle | |http://model.geneontology.org/5900dc7400000539|cyclin-dependent protein serine/threonine kinase inhibitor activity |negatively regulates |mitotic cell cycle | |http://model.geneontology.org/5900dc7400000261|cyclin-dependent protein serine/threonine kinase inhibitor activity |negatively regulates |mitotic cell cycle | |http://model.geneontology.org/5900dc7400000428|cyclin-dependent protein serine/threonine kinase inhibitor activity |negatively regulates |mitotic cell cycle | |http://model.geneontology.org/5900dc7400000409|cyclin-dependent protein serine/threonine kinase inhibitor activity |negatively regulates |mitotic cell cycle | |http://model.geneontology.org/600ced8500002202|protein serine/threonine kinase activity |causally upstream of, negative effect |protein localization to phagophore assembly site | |http://model.geneontology.org/5fadbcf000000000|protein serine/threonine kinase activity |causally upstream of, positive effect |intrinsic apoptotic signaling pathway by p53 class mediator | |http://model.geneontology.org/586fc17a00001662|mRNA 3'-UTR binding |positively regulates |meiotic cell cycle | |http://model.geneontology.org/5e72450500001424|mRNA 3'-UTR binding |negatively regulates |vascular endothelial growth factor receptor signaling pathway | |http://model.geneontology.org/5e72450500001424|mRNA 3'-UTR binding |positively regulates |miRNA-mediated gene silencing by inhibition of translation | |http://model.geneontology.org/5b318d0900000110|protein serine/threonine kinase activity |positively regulates |proteasomal protein catabolic process | |http://model.geneontology.org/59dc728000000287|protein serine/threonine kinase activity |causally upstream of or within |vulval development | |http://model.geneontology.org/598826eb00000085|protein serine/threonine kinase activity |negatively regulates |protein localization to phagophore assembly site | |http://model.geneontology.org/5966411600000017|protein serine/threonine kinase activity |involved in |peptidyl-serine phosphorylation | |http://model.geneontology.org/5966411600000017|protein serine/threonine kinase activity |involved in |protein phosphorylation | |http://model.geneontology.org/5966411600000017|protein serine/threonine kinase activity |directly positively regulates |regulation of protein localization to chromatin | |http://model.geneontology.org/5966411600000744|protein serine/threonine kinase activity |positively regulates |protein localization to chromatin | |http://model.geneontology.org/5dddbf0600000349|nuclear receptor activity |positively regulates |transcription, DNA-templated | |http://model.geneontology.org/5d29221b00001292|nuclear receptor activity |positively regulates |transcription, DNA-templated | |http://model.geneontology.org/5966411600000263|protein serine/threonine kinase activity |regulates |regulation of protein localization to chromatin | |http://model.geneontology.org/5966411600000233|protein serine/threonine kinase activity |enabled by |protein phosphorylation | |http://model.geneontology.org/5b528b1100002161|nuclear glucocorticoid receptor activity |regulates |sex differentiation | |http://model.geneontology.org/5c4605cc00003572|heparan sulfate N-deacetylase activity |causally upstream of or within |heparan sulfate proteoglycan biosynthetic process | |http://model.geneontology.org/580e952200000046|nuclear receptor activity |causally upstream of or within |apoptotic process | |http://model.geneontology.org/5ee8120100000559|GABA-A receptor activity |causally upstream of or within |vascular endothelial cell proliferation | |http://model.geneontology.org/591e948c00000012|acetate kinase (diphosphate) activity |causally upstream of |kidney development | |http://model.geneontology.org/5437882f00000021|acyl-CoA hydrolase activity |causally upstream of |peroxisome fission | |http://model.geneontology.org/5e72450500003254|ubiquitin protein ligase binding |negatively regulates |receptor internalization | |http://model.geneontology.org/5ee8120100000524|ubiquitin protein ligase binding |positively regulates |innate immune response | |http://model.geneontology.org/5fadbcf000000317|JUN kinase activity |causally upstream of or within, positive effect|contact inhibition | |http://model.geneontology.org/5fadbcf000000317|JUN kinase activity |causally upstream of or within, positive effect|cell migration | |http://model.geneontology.org/581e072c00000182|protein serine/threonine kinase activity |positively regulates |DNA damage checkpoint signaling | |http://model.geneontology.org/581e072c00000182|protein serine/threonine kinase activity |positively regulates |replication fork processing | |http://model.geneontology.org/57c4867e00000028|protein serine/threonine kinase activity |negatively regulates |G2/M transition of mitotic cell cycle | |http://model.geneontology.org/57c4867e00000028|protein serine/threonine kinase activity |positively regulates |G2/M transition of mitotic cell cycle | |http://model.geneontology.org/56d1143000003195|JUN kinase activity |positively regulates |mitochondrial depolarization | |http://model.geneontology.org/5666dc6c00000007|protein serine/threonine kinase activity |positively regulates |protein localization to nucleus | |http://model.geneontology.org/5c4605cc00003080|cAMP-dependent protein kinase activity |causally upstream of |negative regulation of GTPase activity | |http://model.geneontology.org/5c4605cc00003080|cAMP-dependent protein kinase activity |causally upstream of |negative regulation of protein kinase activity | |http://model.geneontology.org/59bee34700000000|cAMP-dependent protein kinase activity |directly activates |protein kinase A signaling | |http://model.geneontology.org/581e072c00000182|protein serine/threonine kinase activator activity |positively regulates |DNA damage checkpoint signaling | |http://model.geneontology.org/581e072c00000182|protein serine/threonine kinase activator activity |positively regulates |replication fork processing | |http://model.geneontology.org/567b544200000138|transmembrane receptor protein tyrosine kinase activity |positively regulates |phosphatidylinositol 3-kinase signaling | |http://model.geneontology.org/567b544200000138|transmembrane receptor protein tyrosine kinase activity |positively regulates |mitochondrial depolarization | |http://model.geneontology.org/567b544200000138|transmembrane receptor protein tyrosine kinase activity |positively regulates |mitochondrial fission | |http://model.geneontology.org/5900dc7400001128|transmembrane receptor protein tyrosine kinase activity |negatively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/5900dc7400001128|transmembrane receptor protein tyrosine kinase activity |causally upstream of or within |cell migration | |http://model.geneontology.org/5f421e9000000023|MAP kinase activity |causally upstream of or within, negative effect|positive regulation of cell migration | |http://model.geneontology.org/5f421e9000000023|MAP kinase activity |causally upstream of or within, positive effect|retina development in camera-type eye | |http://model.geneontology.org/5b91dbd100000219|sequence-specific DNA binding |causally upstream of |epiboly | |http://model.geneontology.org/62183af000000835|protein tyrosine phosphatase activity |negatively regulates |T cell receptor signaling pathway | |http://model.geneontology.org/617b481400002690|protein tyrosine kinase activity |regulates |cell morphogenesis | |http://model.geneontology.org/617b481400002690|protein tyrosine kinase activity |regulates |cell growth | |http://model.geneontology.org/617b481400002690|protein tyrosine kinase activity |regulates |epithelial cell differentiation | |http://model.geneontology.org/5941cdbd00000947|sphingolipid transfer activity |directly provides input for |globoside biosynthetic process via lactosylceramide | |http://model.geneontology.org/5a7e68a100000016|protein tyrosine kinase activity |directly positively regulates |import into nucleus | |http://model.geneontology.org/59dc728000000430|non-membrane spanning protein tyrosine kinase activity |causally upstream of or within |positive regulation of cardiac muscle hypertrophy | |http://model.geneontology.org/5666dc6c00000394|protein tyrosine kinase activity |positively regulates |protein localization to plasma membrane | |http://model.geneontology.org/5666dc6c00000394|protein tyrosine kinase activity |positively regulates |cytokine production | |http://model.geneontology.org/56d1143000003195|protein tyrosine kinase activity |positively regulates |IRE1-mediated unfolded protein response | |http://model.geneontology.org/568b0f9600000294|protein tyrosine kinase activity |positively regulates |I-kappaB kinase/NF-kappaB signaling | |http://model.geneontology.org/539b93ec00000010|phosphoprotein phosphatase activity |happens during |mitotic anaphase | |http://model.geneontology.org/613aae0000000915|thioredoxin-disulfide reductase activity |regulates |gastro-intestinal system smooth muscle contraction | |http://model.geneontology.org/613aae0000000915|thioredoxin-disulfide reductase activity |positively regulates |cellular calcium ion homeostasis | |http://model.geneontology.org/613aae0000000915|thioredoxin-disulfide reductase activity |positively regulates |growth hormone secretion | |http://model.geneontology.org/613aae0000000915|thioredoxin-disulfide reductase activity |positively regulates |insulin secretion | |http://model.geneontology.org/613aae0000000915|thioredoxin-disulfide reductase activity |causally upstream of |cellular oxidant detoxification | |http://model.geneontology.org/5667fdd400000696|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity |negatively regulates |insulin receptor signaling pathway via phosphatidylinositol 3-kinase | |http://model.geneontology.org/57c4867e00000002|cell adhesion molecule binding |positively regulates |presynaptic active zone assembly | |http://model.geneontology.org/5835403200000017|stem cell factor receptor activity |negatively regulates |erythrocyte differentiation | |http://model.geneontology.org/60ff660000000753|insulin-activated receptor activity |causally upstream of, negative effect |protein import into nucleus | |http://model.geneontology.org/581e072c00000123|histone methyltransferase activity |positively regulates |cellular response to oxidative stress | |http://model.geneontology.org/5966411600000155|MAP-kinase scaffold activity |positively regulates |MAPK cascade | |http://model.geneontology.org/5b528b1100000451|methylcytosine dioxygenase activity |causally upstream of or within |Notch signaling pathway | |http://model.geneontology.org/5b528b1100000451|methylcytosine dioxygenase activity |causally upstream of or within |Wnt signaling pathway | |http://model.geneontology.org/57c7dc7500000004|thiamine phosphate phosphatase activity |causally upstream of |regulation of sensory perception of pain | |http://model.geneontology.org/5b528b1100000451|methylcytosine dioxygenase activity |causally upstream of or within |cell morphogenesis involved in differentiation | |http://model.geneontology.org/5b528b1100002293|pre-mRNA binding |happens during |gastrulation | |http://model.geneontology.org/5f46c3b700003298|lipoteichoic acid binding |causally upstream of or within, positive effect|defense response to bacterium | |http://model.geneontology.org/5ee8120100001217|transmembrane receptor protein phosphatase activity |causally upstream of or within |negative regulation of Wnt signaling pathway | |http://model.geneontology.org/5ee8120100001217|transmembrane receptor protein phosphatase activity |causally upstream of or within |anterior/posterior pattern specification | |http://model.geneontology.org/595a9ee700000584|frizzled binding |causally upstream of, positive effect |transcription by RNA polymerase II | |http://model.geneontology.org/5c4605cc00001638|BMP receptor binding |causally upstream of or within, negative effect|limb joint morphogenesis | |http://model.geneontology.org/595a9ee700000584|frizzled binding |causally upstream of or within |cell migration | |http://model.geneontology.org/5941cdbd00000308|tubulin-glycine ligase activity |causally upstream of or within |brainstem precerebellar neuron precursor migration | |http://model.geneontology.org/5667fdd400000077|small conjugating protein ligase activity |directly activates |protein lipidation involved in autophagosome assembly | |http://model.geneontology.org/5667fdd400000077|ubiquitin-like protein transferase activity |directly activates |protein lipidation involved in autophagosome assembly | |http://model.geneontology.org/5825564b00000099|DNA-binding transcription factor activity |causally upstream of |parathyroid gland development | |http://model.geneontology.org/5825564b00000099|DNA-binding transcription factor activity |causally upstream of |thymus development | |http://model.geneontology.org/5825564b00000099|DNA-binding transcription factor activity |causally upstream of or within |parathyroid gland development | |http://model.geneontology.org/567b544200000138|DNA-binding transcription factor activity |directly activates |transcription by RNA polymerase II | |http://model.geneontology.org/56aac7ad00000147|DNA-binding transcription factor activity |positively regulates |positive regulation of nitric oxide biosynthetic process | |http://model.geneontology.org/581e072c00000336|DNA-binding transcription factor activity |positively regulates |mRNA transcription by RNA polymerase II | |http://model.geneontology.org/57c82fad00000619|DNA-binding transcription factor activity |causally upstream of |innate vocalization behavior | |http://model.geneontology.org/57c82fad00000619|DNA-binding transcription factor activity |causally upstream of |regulation of action potential | |http://model.geneontology.org/57c82fad00000403|DNA-binding transcription factor activity |causally upstream of or within |endoderm development | |http://model.geneontology.org/57c82fad00000403|DNA-binding transcription factor activity |causally upstream of or within |cell differentiation | |http://model.geneontology.org/57c82fad00000403|DNA-binding transcription factor activity |causally upstream of or within |anatomical structure morphogenesis | |http://model.geneontology.org/56d1143000003249|GTPase activator activity |negatively regulates |Rho protein signal transduction | |http://model.geneontology.org/56d1143000003249|GTPase activator activity |negatively regulates |angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure | |http://model.geneontology.org/5e72450500003254|guanyl-nucleotide exchange factor activity |positively regulates |receptor internalization | |http://model.geneontology.org/5e72450500002742|guanyl-nucleotide exchange factor activity |positively regulates |membrane fission | |http://model.geneontology.org/5df932e000000920|glucose 6-phosphate:inorganic phosphate antiporter activity |causally upstream of or within |phagosome maturation | |http://model.geneontology.org/5c4605cc00002729|DNA-binding transcription factor activity |causally upstream of, positive effect |positive regulation of sorocarp spore cell differentiation | |http://model.geneontology.org/5b528b1100001637|DNA-binding transcription factor activity |causally upstream of or within |regulation of gene expression | |http://model.geneontology.org/5900dc7400000744|DNA-binding transcription factor activity |directly activates |transcription, DNA-templated | |http://model.geneontology.org/5b91dbd100000370|DNA-binding transcription factor activity |causally upstream of or within |positive regulation of transcription by RNA polymerase II | |http://model.geneontology.org/5ae3b0f600000408|DNA-binding transcription factor activity |positively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/59bee34700000234|DNA-binding transcription factor activity |directly positively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/586fc17a00002173|DNA-binding transcription factor activity |negatively regulates |cell differentiation | |http://model.geneontology.org/586fc17a00002173|DNA-binding transcription factor activity |negatively regulates |canonical glycolysis | |http://model.geneontology.org/5835403200000017|DNA-binding transcription factor activity |positively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/613aae0000000338|histone dopaminyltransferase activity |positively regulates |dopamine secretion | |http://model.geneontology.org/593423e000000026|DNA-binding transcription factor activity |regulates |brassinosteroid mediated signaling pathway | |http://model.geneontology.org/595a9ee700000584|DNA-binding transcription factor activity |positively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/593423e000000014|DNA-binding transcription factor activity |causally upstream of, positive effect |pancreas morphogenesis | |http://model.geneontology.org/593423e000000014|DNA-binding transcription factor activity |causally upstream of or within |embryonic digestive tract morphogenesis | |http://model.geneontology.org/5fadbcf000000317|Rho-dependent protein serine/threonine kinase activity |causally upstream of or within, positive effect|contact inhibition | |http://model.geneontology.org/5fadbcf000000317|Rho-dependent protein serine/threonine kinase activity |causally upstream of or within, positive effect|cell migration | |http://model.geneontology.org/5e72450500002742|acetylation-dependent protein binding |positively regulates |protein targeting | |http://model.geneontology.org/5667fdd400000228|DNA-binding transcription factor activity |positively regulates |positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress| |http://model.geneontology.org/5667fdd400000228|DNA-binding transcription factor activity |positively regulates |mRNA transcription by RNA polymerase II | |http://model.geneontology.org/5e72450500002742|dephospho-[reductase kinase] kinase activity |positively regulates |protein targeting | |http://model.geneontology.org/5e72450500002742|dephospho-[reductase kinase] kinase activity |positively regulates |clathrin coat disassembly | |http://model.geneontology.org/6197061700003613|cytokine activity |causally upstream of |positive regulation of I-kappaB kinase/NF-kappaB signaling | |http://model.geneontology.org/5e72450500003254|dephospho-[reductase kinase] kinase activity |positively regulates |receptor internalization | |http://model.geneontology.org/5666dc6c00000094|DNA-binding transcription factor activity |results_in |nucleocytoplasmic transport | |http://model.geneontology.org/5666dc6c00000621|DNA-binding transcription factor activity |positively regulates |protein localization to plasma membrane | |http://model.geneontology.org/5666dc6c00000621|DNA-binding transcription factor activity |positively regulates |protein oxidation | |http://model.geneontology.org/5666dc6c00000094|DNA-binding transcription factor activity |directly activates |transcription by RNA polymerase II | |http://model.geneontology.org/5666dc6c00000094|DNA-binding transcription factor activity |causally upstream of |transcription by RNA polymerase II | |http://model.geneontology.org/5662325600000049|DNA-binding transcription factor activity |positively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/5666dc6c00000623|DNA-binding transcription factor activity |regulates |transcription, DNA-templated | |http://model.geneontology.org/5667fdd400000001|DNA-binding transcription factor activity |directly activates |transcription by RNA polymerase II | |http://model.geneontology.org/5666dc6c00000034|DNA-binding transcription factor activity |negatively regulates |apoptotic process | |http://model.geneontology.org/5482537600000040|DNA-binding transcription factor activity |positively regulates |apoptotic process | |http://model.geneontology.org/536d71c500000004|DNA-binding transcription factor activity |positively regulates |gene expression | |http://model.geneontology.org/5f421e9000000091|histone pre-mRNA stem-loop binding |causally upstream of or within |oogenesis | |http://model.geneontology.org/5f421e9000000091|histone pre-mRNA stem-loop binding |causally upstream of or within |embryonic cleavage | |http://model.geneontology.org/5fce9b7300002679|DNA-binding transcription factor activity |happens during |M phase | |http://model.geneontology.org/59dc728000000324|dynein intermediate chain binding |regulates |microtubule anchoring at centrosome | |http://model.geneontology.org/60897d8500000154|DNA-binding transcription factor activity |causally upstream of or within |male meiosis I | |http://model.geneontology.org/5e72450500003254|AP-2 adaptor complex binding |positively regulates |receptor internalization | |http://model.geneontology.org/57c82fad00000403|RNA polymerase II general transcription initiation factor activity |causally upstream of or within |cell differentiation | |http://model.geneontology.org/59dc728000000351|transcription coactivator activity |happens during |mitotic anaphase B | |http://model.geneontology.org/5d29221b00002678|Wnt-activated receptor activity |negatively regulates |neuron death in response to oxidative stress | |http://model.geneontology.org/5e72450500002742|clathrin adaptor activity |positively regulates |clathrin coat assembly | |http://model.geneontology.org/595a9ee700000584|Wnt-activated receptor activity |causally upstream of or within |cell migration | |http://model.geneontology.org/5e72450500003254|clathrin adaptor activity |positively regulates |receptor internalization | |http://model.geneontology.org/5e72450500003254|clathrin adaptor activity |positively regulates |AMPA glutamate receptor clustering | |http://model.geneontology.org/5e72450500003254|clathrin adaptor activity |causally upstream of |membrane fission | |http://model.geneontology.org/5ae3b0f600000855|Wnt-activated receptor activity |causally upstream of or within, positive effect|canonical Wnt signaling pathway | |http://model.geneontology.org/586fc17a00001081|palmitoyltransferase activity |negatively regulates |protein localization to plasma membrane | |http://model.geneontology.org/595a9ee700000584|Wnt-activated receptor activity |causally upstream of, positive effect |transcription by RNA polymerase II | |http://model.geneontology.org/5900dc7400001128|Wnt-activated receptor activity |causally upstream of or within |cell migration | |http://model.geneontology.org/5e72450500002742|kinase activity |negatively regulates |membrane fission | |http://model.geneontology.org/5c4605cc00000258|kinase activity |causally upstream of |erythrocyte development | |http://model.geneontology.org/5e72450500003294|kinase activity |causally upstream of or within |notochord cell vacuolation | |http://model.geneontology.org/57c4867e00000240|kinase activity |negatively regulates |memory | |http://model.geneontology.org/5666dc6c00000376|kinase activity |negatively regulates |apoptotic process | |http://model.geneontology.org/5667fdd400000077|kinase activity |positively regulates |protein localization to phagophore assembly site | |http://model.geneontology.org/595a9ee700000584|kinase activity |causally upstream of, negative effect |transcription by RNA polymerase II | |http://model.geneontology.org/617b481400000559|peptide-lysine-N-acetyltransferase activity |causally upstream of, positive effect |lipid droplet disassembly | |http://model.geneontology.org/5437882f00000034|peroxiredoxin activity |depends on |NADPH regeneration | |http://model.geneontology.org/5e72450500002742|cargo adaptor activity |positively regulates |clathrin coat assembly | |http://model.geneontology.org/5ee8120100002899|protein sequestering activity |negatively regulates |protein import into nucleus | |http://model.geneontology.org/5e72450500003254|ubiquitin ligase inhibitor activity |negatively regulates |receptor internalization | |http://model.geneontology.org/5f46c3b700000011|cargo adaptor activity |causally upstream of or within |retrograde axonal protein transport | |http://model.geneontology.org/60d5209a00001290|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|causally upstream of or within, positive effect|cardiac conduction | |http://model.geneontology.org/5e72450500002742|ubiquitin ligase inhibitor activity |negatively regulates |protein targeting | |http://model.geneontology.org/5c4605cc00003572|heparan sulfate binding |negatively regulates |Wnt receptor internalization | |http://model.geneontology.org/5716c41300000082|palmitoleoyltransferase activity |causally upstream of |Wnt protein secretion | |http://model.geneontology.org/5716c41300000082|palmitoleoyltransferase activity |causally upstream of |Wnt signaling pathway | |http://model.geneontology.org/5716c41300000082|palmitoleoyltransferase activity |causally upstream of |Golgi to plasma membrane protein transport | |http://model.geneontology.org/5e72450500003254|protein sequestering activity |negatively regulates |receptor internalization | |http://model.geneontology.org/5e72450500003254|protein sequestering activity |negatively regulates |AMPA glutamate receptor clustering | |http://model.geneontology.org/5e72450500002742|protein sequestering activity |positively regulates |protein targeting | |http://model.geneontology.org/5f46c3b700004346|transcription corepressor activity |causally upstream of or within, negative effect|secondary heart field specification | |http://model.geneontology.org/5f46c3b700004346|transcription corepressor activity |causally upstream of or within, positive effect|secondary heart field specification | |http://model.geneontology.org/5ce58dde00000064|phosphatidylinositol 3-kinase activity |regulates |B cell affinity maturation | |http://model.geneontology.org/613aae0000000885|cadherin binding |causally upstream of |cytoplasmic sequestering of protein | |http://model.geneontology.org/5970219a00000566|actin filament binding |regulates |mitochondrion localization | |http://model.geneontology.org/5e72450500002742|actin filament binding |positively regulates |membrane fission | |http://model.geneontology.org/5f46c3b700002608|mitogen-activated protein kinase binding |happens during |meiotic cell cycle phase | |http://model.geneontology.org/5e72450500002742|actin filament binding |transports or maintains localization of |membrane fission | |http://model.geneontology.org/57c4867e00000150|mRNA base-pairing post-transcriptional repressor activity |negatively regulates |extracellular matrix assembly | |http://model.geneontology.org/568b0f9600000093|promoter-specific chromatin binding |directly positively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/5fadbcf000000317|RNA binding |causally upstream of, positive effect |neural crest cell migration | |http://model.geneontology.org/60418ffa00002431|aspartic-type peptidase activity |causally upstream of or within, positive effect|pyroptosis | |http://model.geneontology.org/5ce58dde00000937|SUMO-ubiquitin ligase activity |causally upstream of, positive effect |granulocyte differentiation | |http://model.geneontology.org/5b91dbd100002343|RNA binding |causally upstream of |lens fiber cell differentiation | |http://model.geneontology.org/5ce58dde00001143|RNA binding |causally upstream of or within, positive effect|mRNA metabolic process | |http://model.geneontology.org/586fc17a00001587|RNA binding |causally upstream of |positive regulation of type I interferon-mediated signaling pathway | |http://model.geneontology.org/598826eb00000085|scaffold protein binding |happens during |cellular response to rapamycin | |http://model.geneontology.org/598826eb00000123|scaffold protein binding |happens during |cellular response to rapamycin | |http://model.geneontology.org/598826eb00000120|scaffold protein binding |happens during |cellular response to rapamycin | |http://model.geneontology.org/5e72450500003254|scaffold protein binding |positively regulates |receptor internalization | |http://model.geneontology.org/5e72450500003254|scaffold protein binding |positively regulates |membrane fission | |http://model.geneontology.org/5e72450500002742|scaffold protein binding |positively regulates |clathrin coat assembly | |http://model.geneontology.org/5e72450500002742|scaffold protein binding |positively regulates |membrane fission | |http://model.geneontology.org/593423e000000084|cysteine-type endopeptidase activity involved in execution phase of apoptosis |regulates |fat cell apoptotic process | |http://model.geneontology.org/598826eb00000001|scaffold protein binding |happens during |cellular response to rapamycin | |http://model.geneontology.org/5e72450500002742|scaffold protein binding |causally upstream of, positive effect |AMPA glutamate receptor clustering | |http://model.geneontology.org/5e72450500002742|scaffold protein binding |transports or maintains localization of |membrane fission | |http://model.geneontology.org/5d29221b00001552|mRNA binding |causally upstream of or within, negative effect|microglial cell activation | |http://model.geneontology.org/5d29221b00001552|mRNA binding |causally upstream of or within, negative effect|reactive gliosis | |http://model.geneontology.org/5d29221b00001552|mRNA binding |causally upstream of or within, positive effect|negative regulation of translation | |http://model.geneontology.org/5ee8120100003329|mRNA binding |negatively regulates |mRNA catabolic process | |http://model.geneontology.org/5ee8120100003329|mRNA binding |causally upstream of, positive effect |actin cytoskeleton organization | |http://model.geneontology.org/5ee8120100002909|mRNA binding |causally upstream of or within |lens fiber cell development | |http://model.geneontology.org/586fc17a00001263|mRNA binding |negatively regulates |translation | |http://model.geneontology.org/5c4605cc00000939|monoamine oxidase activity |causally upstream of |serotonin receptor signaling pathway | |http://model.geneontology.org/5c4605cc00000939|monoamine oxidase activity |causally upstream of |dopamine receptor signaling pathway | |http://model.geneontology.org/613aae0000000885|phosphatase activity |directly negatively regulates |cytoplasmic sequestering of protein | |http://model.geneontology.org/59b38c1100000331|diguanylate cyclase activity |positively regulates |cell surface receptor signaling pathway involved in cell-cell signaling | |http://model.geneontology.org/59bee34700000000|diguanylate cyclase activity |directly provides input for |c-di-GMP signaling | |http://model.geneontology.org/539b93ec00000010|phosphatase activity |existence overlaps |mitotic telophase | |http://model.geneontology.org/60ad85f700002003|phosphatase activity |causally upstream of or within |purine deoxyribonucleotide metabolic process | |http://model.geneontology.org/56cbaef000000079|protein-macromolecule adaptor activity |positively regulates |anterograde synaptic vesicle transport | |http://model.geneontology.org/5e72450500002742|protein-macromolecule adaptor activity |positively regulates |actin polymerization or depolymerization | |http://model.geneontology.org/5e72450500002742|protein-macromolecule adaptor activity |causally upstream of |clathrin coat assembly | |http://model.geneontology.org/5824c51a00000007|protein-macromolecule adaptor activity |causally upstream of or within |endoderm development | |http://model.geneontology.org/5824c51a00000007|protein-macromolecule adaptor activity |causally upstream of or within |receptor internalization | |http://model.geneontology.org/56d1143000003110|protein-macromolecule adaptor activity |positively regulates |anterograde synaptic vesicle transport | |http://model.geneontology.org/5e72450500002742|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity |positively regulates |membrane fission | |http://model.geneontology.org/60ff660000001405|transforming growth factor beta receptor binding |causally upstream of or within |negative regulation of dauer larval development | |http://model.geneontology.org/5835403200000017|histone deacetylase activity |directly inhibits |transcription by RNA polymerase II | |http://model.geneontology.org/5900dc7400000890|G protein-coupled receptor activity |causally upstream of or within |negative regulation of lipid catabolic process | |http://model.geneontology.org/5e72450500001671|signaling receptor binding |causally upstream of or within, positive effect|purinergic nucleotide receptor signaling pathway | |http://model.geneontology.org/5e72450500001671|fibroblast growth factor receptor binding |causally upstream of or within, positive effect|MAPK cascade | |http://model.geneontology.org/57f1b14b00000286|signaling receptor binding |negatively regulates |neuron projection development | |http://model.geneontology.org/57f1b14b00000286|signaling receptor binding |positively regulates |neuron projection development | |http://model.geneontology.org/57f1b14b00000286|signaling receptor binding |positively regulates |regulation of GTPase activity | |http://model.geneontology.org/57f1b14b00000286|signaling receptor binding |positively regulates |protein localization to cell surface | |http://model.geneontology.org/57f1b14b00000286|signaling receptor binding |directly activates |membrane protein ectodomain proteolysis | |http://model.geneontology.org/57f1b14b00000286|signaling receptor binding |directly inhibits |membrane protein ectodomain proteolysis | |http://model.geneontology.org/59c8885900000374|cytokine receptor binding |positively regulates |receptor signaling pathway via JAK-STAT | |http://model.geneontology.org/593423e000000014|endoribonuclease activity |causally upstream of, positive effect |pancreas morphogenesis | |http://model.geneontology.org/593423e000000014|endoribonuclease activity |causally upstream of or within |embryonic digestive tract morphogenesis | |http://model.geneontology.org/59cde02c00000040|transmembrane signaling receptor activity |causally upstream of |intestinal stem cell homeostasis | |http://model.geneontology.org/5900dc7400001096|intracellular cGMP-activated cation channel activity |causally upstream of, positive effect |response to heat | |http://model.geneontology.org/59b38c1100000136|cytokine receptor activity |causally upstream of, positive effect |activation of Janus kinase activity | |http://model.geneontology.org/56d1143000000320|calcium channel regulator activity |regulates |calcium ion transmembrane transport | |http://model.geneontology.org/59c8885900000169|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |positively regulates |activation of protein kinase C activity | |http://model.geneontology.org/5745387b00001048|voltage-gated ion channel activity |causally upstream of |regulation of postsynaptic cytosolic calcium ion concentration | |http://model.geneontology.org/6086f4f200000298|SNAP receptor activity |directly positively regulates |autophagosome-lysosome fusion | |http://model.geneontology.org/5716c41300000082|SNAP receptor activity |causally upstream of |Wnt signaling pathway | |http://model.geneontology.org/5f46c3b700001617|lipid transporter activity |happens during |M phase | |http://model.geneontology.org/593423e000000554|cyclin-dependent protein serine/threonine kinase activity |causally upstream of or within |chromatin assembly | |http://model.geneontology.org/5ee8120100003562|L-glutamate transmembrane transporter activity |causally upstream of or within |cellular response to organic cyclic compound | |http://model.geneontology.org/5745387b00001247|acetylcholine transmembrane transporter activity |negatively regulates |memory | |http://model.geneontology.org/5745387b00001247|acetylcholine transmembrane transporter activity |negatively regulates |synaptic transmission, cholinergic | |http://model.geneontology.org/580685bd00000071|cation channel activity |positively regulates |membrane depolarization | |http://model.geneontology.org/5745387b00001247|acetylcholine transmembrane transporter activity |positively regulates |olfactory learning | |http://model.geneontology.org/5716c41300000574|ATP binding |negatively regulates |glycolytic process | |http://model.geneontology.org/5666dc6c00000417|cystathionine gamma-lyase activity |positively regulates |hydrogen sulfide biosynthetic process | |http://model.geneontology.org/57ec3a7e00000075|GTP binding |regulates |biological_process | |http://model.geneontology.org/57c82fad00000897|GTP binding |negatively regulates |actin filament polymerization | |http://model.geneontology.org/57c82fad00000897|GTP binding |positively regulates |myosin II filament assembly | |http://model.geneontology.org/5667fdd400000802|GTP binding |regulates |biological_process | |http://model.geneontology.org/5b91dbd100000065|serine-type carboxypeptidase activity |happens during |cellular response to nitrogen starvation | |http://model.geneontology.org/5667fdd400000077|cysteine-type endopeptidase activity |directly activates |protein delipidation | |http://model.geneontology.org/57c4867e00000026|endopeptidase activity |happens during |mitotic M phase | |http://model.geneontology.org/57c4867e00000026|endopeptidase activity |negatively regulates |mitotic sister chromatid cohesion | |http://model.geneontology.org/57ec3a7e00000075|protein binding |regulates |biological_process | |http://model.geneontology.org/57f1b14b00000286|protein binding |negatively regulates |membrane protein ectodomain proteolysis | |http://model.geneontology.org/5c4605cc00004193|cysteine-type endopeptidase activity |causally upstream of or within |pyroptosis | |http://model.geneontology.org/57c82fad00000403|protein binding |causally upstream of or within |cell differentiation | |http://model.geneontology.org/57c4867e00000244|protein binding |happens during |mitotic S phase | |http://model.geneontology.org/5da4ff8500000167|protein binding |causally upstream of or within |NIK/NF-kappaB signaling | |http://model.geneontology.org/5666dc6c00000394|protein binding |positively regulates |apoptotic cell clearance | |http://model.geneontology.org/5667fdd400000077|protein binding |directly provides input for |substrate localization to autophagosome | |http://model.geneontology.org/5d29221b00001995|protein binding |causally upstream of or within, positive effect|gene expression | |http://model.geneontology.org/5d29221b00000670|protein binding |causally upstream of or within |intermediate filament organization | |http://model.geneontology.org/5ce58dde00001143|protein binding |causally upstream of or within, positive effect|mRNA metabolic process | |http://model.geneontology.org/5ce58dde00000380|protein binding |causally upstream of or within, positive effect|protein polyubiquitination | |http://model.geneontology.org/598826eb00000261|protein binding |acts upstream of |synaptic vesicle fusion to presynaptic active zone membrane | |http://model.geneontology.org/5900dc7400000000|protein binding |regulates |male sex differentiation | |http://model.geneontology.org/586fc17a00001587|protein binding |directly activates |activation of Janus kinase activity | |http://model.geneontology.org/5900dc7400000261|protein binding |positively regulates |mitotic cell cycle | |http://model.geneontology.org/5900dc7400000261|protein binding |directly inhibits |positive regulation of transcription by RNA polymerase II | |http://model.geneontology.org/600ced8500001645|protein binding |causally upstream of or within |epithelial structure maintenance | |http://model.geneontology.org/5c4605cc00002140|metallopeptidase activity |causally upstream of or within |insulin-like growth factor receptor signaling pathway | |http://model.geneontology.org/5e72450500002742|protein binding |positively regulates |membrane fission | |http://model.geneontology.org/5e72450500002742|protein binding |positively regulates |clathrin coat assembly | |http://model.geneontology.org/5f46c3b700002032|G protein-coupled acetylcholine receptor activity |causally upstream of or within |cardiac conduction system development | |http://model.geneontology.org/61e0e55600000338|protein binding |positively regulates |regulation of autophagosome assembly | |http://model.geneontology.org/5e72450500002742|ATP hydrolysis activity |negatively regulates |receptor diffusion trapping | |http://model.geneontology.org/5e72450500003254|ATP hydrolysis activity |positively regulates |receptor internalization | |http://model.geneontology.org/5e72450500003254|ATP hydrolysis activity |positively regulates |AMPA glutamate receptor clustering | |http://model.geneontology.org/613aae0000000338|protein binding |directly positively regulates |gene expression | |http://model.geneontology.org/5900dc7400000428|transcription factor binding |negatively regulates |transcription by RNA polymerase II | |http://model.geneontology.org/5900dc7400000428|transcription factor binding |directly inhibits |positive regulation of transcription by RNA polymerase II |
vanaukenk commented 1 year ago

Thank you so much @balhoff This should keep us busy for a while :-)

pgaudet commented 1 year ago

@balhoff some models I dont find in Noctua - for example http://model.geneontology.org/5966411600000233

http://model.geneontology.org/598826eb00000261

How come ?

balhoff commented 1 year ago

@pgaudet that's a very good question! I checked the first one to see if it was marked "delete", but it doesn't seem to be.

pgaudet commented 1 year ago

ok. Weird

balhoff commented 1 year ago

@pgaudet that model is here: https://github.com/geneontology/noctua-models/blob/master/models/5966411600000233.ttl

It's marked "delete" there, so it isn't loaded into Noctua. But that change happened 7 months ago: https://github.com/geneontology/noctua-models/commit/c1415f553f8767d9d35a3ea90d26384dfecba4a2#diff-87d08b64703ef6e9e9b656c1d6ad4d34e7aa4997ab3f2d6a4232d330ab256c9d

@kltm could the triplestore be very out of date?

kltm commented 1 year ago

@balhoff The best way to check would be to look for newer models or annotation dates. If the "internal" endpoint, I wonder if "deleted" models are actually filtered?

balhoff commented 1 year ago

@kltm that model says "development" in the endpoint: https://api.triplydb.com/s/RuwQG_fGT

pgaudet commented 1 year ago

Sounds like this will have to be re-ran. Next time @balhoff can you also query the model status? (many of the other ones I checked were dev)

Thank you!

balhoff commented 1 year ago

@kltm I think the "internal" endpoint has a content problem. Compare these queries:

kltm commented 1 year ago

@balhoff Yes, at the very least, "prod" should be a subset of "internal". internal: -rw-r--r-- 1 ubuntu ubuntu 36464689152 Apr 3 20:49 blazegraph.jnl production: -rw-r--r-- 1 ubuntu ubuntu 36464689152 Apr 3 21:05 blazegraph.jnl So at least we know they are getting updated. IIRC, blazegraph creates journals in sized chunks, so the identical size may be indicative of nothing. I've restarted the internal server and nothing seems amiss otherwise. No change. This would maybe point to an issue in the construction of the "internal" blazegraph journal? @balhoff @dustine32 Looking through the Jenkinsfile, it seems that the journals are a product of the Mega-make:

target/blazegraph.jnl: $(BGJAR) target/rdf target/noctua-models
        du -sh target
        du -sh target/*
        free -h
        ls -AlF /tmp
        JAVA_OPTS=-Xmx$(BGMEM) blazegraph-runner --journal=target/blazegraph.jnl
 --properties=conf/blazegraph.properties load --use-ontology-graph $(LOAD_TARGET
S)
        du -sh target
        du -sh target/*
        free -h
        ls -AlF /tmp
        JAVA_OPTS=-Xmx$(BGMEM) blazegraph-runner --journal=target/blazegraph.jnl
 --properties=conf/blazegraph.properties reason --source-graphs-query=$(CAM_GRAP
H_QUERY) --ontology=$(GO_GRAPHSTORE_URI) --append-graph-name="_inferred"
        du -sh target
        du -sh target/*
        free -h

target/blazegraph-internal.jnl: target/blazegraph.jnl
        cp $< $@
        JAVA_OPTS=-Xmx$(BGMEM) blazegraph-runner --journal=$@ update sparql/insert/insert_noctua_metadata.sparql
        JAVA_OPTS=-Xmx$(BGMEM) blazegraph-runner --journal=$@ update sparql/insert/insert_ontology_metadata.sparql
        JAVA_OPTS=-Xmx$(BGMEM) blazegraph-runner --journal=$@ update sparql/insert/insert_reflexive_subclass_closure.sparql

target/blazegraph-production.jnl: target/blazegraph-internal.jnl
        cp $< $@
        JAVA_OPTS=-Xmx$(BGMEM) blazegraph-runner --journal=$@ update sparql/delete/delete_non_production.sparql

It looks like there is a "source" blazegraph, that is used for the "internal" blazegraph, which is used for the "prod" blazegraph. That is not consistent with what we're seeing.

kltm commented 1 year ago

While this is suuuper worrying, it's not really in public right now, so we're going to probably not get to the bottom of this before the meeting. After the meeting, @kltm and @dustine32 will manually run the process in the Makefile on a v/v/small noctua-model set and see if we can simulate the problem. We're guessing some kind of build issues at this point because of the tmpfs and use of docker--no dirty workspaces.

pgaudet commented 1 year ago

Google doc with query results: https://docs.google.com/spreadsheets/d/1JS6IwCoQjpwsON1OUc0bVpb2D2jwGEj846LpXRp40eU/edit#gid=0

vanaukenk commented 1 year ago

Query that includes model state and title (added as a new sheet to Google spreadsheet above):

PREFIX dc: <http://purl.org/dc/elements/1.1/>
PREFIX cd: <http://citydata.wu.ac.at/ns#>
PREFIX owl: <http://www.w3.org/2002/07/owl#>
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>
PREFIX bds: <http://www.bigdata.com/rdf/search#>
PREFIX part_of: <http://purl.obolibrary.org/obo/BFO_0000050>
PREFIX BP: <http://purl.obolibrary.org/obo/GO_0008150>
PREFIX MF: <http://purl.obolibrary.org/obo/GO_0003674>
PREFIX CC: <http://purl.obolibrary.org/obo/GO_0005575>

SELECT DISTINCT ?cam (STR(?mf_label) AS ?mf_name) (STR(?rel_label) AS ?rel_name) (STR(?bp_label) AS ?bp_name) ?state ?title
WHERE {
  ?bp rdf:type BP: .
  ?mf rdf:type MF: .
  ?rel a owl:ObjectProperty .
  # This pattern selects asserted GO-CAM graphs
  ?cam <http://geneontology.org/lego/modelstate> ?state .
  ?cam dc:title ?title .
  GRAPH ?cam {
    ?mf ?rel ?bp .
  }
  GRAPH ?cam {
    ?mf rdf:type ?asserted_mf_type .
    FILTER(?asserted_mf_type != MF:)
    FILTER(?asserted_mf_type != owl:NamedIndividual)
  }
  GRAPH ?cam {
    ?bp rdf:type ?asserted_bp_type .
    FILTER(?asserted_bp_type != owl:NamedIndividual)
  }
  ?asserted_mf_type rdfs:subClassOf MF: .
  ?asserted_bp_type rdfs:subClassOf BP: .
  ?asserted_mf_type rdfs:label ?mf_label .
  ?asserted_bp_type rdfs:label ?bp_label .
  ?rel rdfs:label ?rel_label .
  FILTER(?rel != part_of:)
  FILTER(isIRI(?mf))
  FILTER(isIRI(?bp))
}
#LIMIT 1000
kltm commented 1 year ago

@balhoff Once this release is finalized (today or tomorrow), @pgaudet was wondering if you could re-run to get the latest version on prod.

kltm commented 1 year ago

@vanaukenk , @balhoff figured out it was the DNS and I believe we have it corrected now.