Existing Reactome reactions 74247 and 74258 capture the two-step conversion of hypoxanthine to urate with generation of H2O2. An alternative form of the same enzyme catalyzes the same two steps but with the reduction of NAD+ to NADH + H+, and this is said to be major route under normal physiological conditions (e.g., Ichida et al. 1212 - PMID: 23203137). So create the two reactions that use NAD+.
deustp01
commented
3 years ago
Existing Reactome reactions 74247 and 74258 capture the two-step conversion of hypoxanthine to urate with generation of H2O2. An alternative form of the same enzyme catalyzes the same two steps but with the reduction of NAD+ to NADH + H+, and this is said to be major route under normal physiological conditions (e.g., Ichida et al. 1212 - PMID: 23203137). So create the two reactions that use NAD+.