Open ukemi opened 2 years ago
Trying to evidence the mouse model for this pathway is extremely difficult. It may be because mice don't degrade KS in the same way humans do or because the distribution of KS is different in rats and mice than it is in humans, and the appropriate measurements have not been done (PMID:33266180, PMID:30528226, PMID:3160342, PMID:29396849).
Aside from the BP tweak to reaction R-HSA-2046239, I don't see anything to fix now in the human pathway. Two items for the future:
On the 95% - 5% rule, I'd be inclined to set this one aside for now and knock off some of the others that look more straightforward. Pushing edge cases that show real differences between species is important, but this looks like one in which the data are limited enough so that it will be hard to sort out what's different from what just hasn't been studied very well.