Insulin Receptor Recycling (R-HSA-77387)

[ukemi]

• [x] Make mouse model---gomodel:62f58d8800001119
• [x] Should the pathway be assigned to insulin receptor recycling (GO:0038020)?
• [x] Should IDA in R-HSA-74723 be IDE (UniProtKB:P14735)? Typo here? R-HSA-74723 is "endodome acidification". "Insulin degradation" is R-HSA-74730, and that reaction has been updated to have IDE (P14735) as catalyst.
• [x] Can cathepsin D (P07339) also catalyze endosomal insulin degradation - check PMID: 9793760 (review of evidence that IDE can degrade insulin), PMID:27703010 (perturbing Zn++ transport into endosomes reduces both IDE and cathepsin D activities) However- PMID: 8300632 presents evidence that IDE is unlikely to mediate most insulin degradation and suggests a cathepsin D-like activity is the major relevant enzyme, and Authier et al. 2002 PMID: 11779865 - a later paper from the same group - shows the activity to be cathepsin D. Meanwhile Shen et al. 2006 - PMID: 17051221 - provide more evidence for a physiological role for IDE in insulin degradation. Focus on these two papers to clean up Reactome annotation of insulin degradation. DONE by making a candidate set of CTSD and IDE and making this set the physical entity in the catlystActivity for the reaction - same use of candidates to cover weak and contradictory evidence as in the afterthought item in #183 , with the same need for future thought
• [x] #199

[deustp01]

Last to-do item converted into its own ticket, #199, so what's left of this ticket is completed.