Regulation of insulin secretion (R-HSA-422356)

[ukemi]

• [ ] Make mouse models gomodel:62f58d8800002020 gomodel:62f58d8800002184
• [ ] Expand on the glucose pathway? It is thought that the glucose import results in glycolysis and subsequent increase in ATP, which in turn downregulates the rectifying potassium channel. PMID:34440773, PMID:16321791. And PMID:35728586, which also may be useful for general integration of energy metabolism
• [ ] Quoting #192 should we update both of these pathways, with PMID: 35728586 as a possible guide or anyway a starting point for exploring further?
• [ ] The activity of the potassium channel is a bit weird. It is itself missing from the Reactome pathway. Should it be added?
• [ ] The ABCC8 subunit binds the nucleotides. The evidence is on my mouse models.
• [ ] The zinc binds the ABCC8 subunit extracellularly and inhibits the potassium channel. PMID:15613469