Should we just do a general update the whole insulin receptor recycling pathway (R-HSA-77387)?

[deustp01]

• Start with these two reviews: PMID:31658625, PMID:34209489.
• A relevant protein family, sorting nexins, SNX1,2,..., unknown to Reactome - PMID: 9819414, PMID: 12461558.
• Clathrin-independent endocytosis - one of two modes of INSR uptake and recycling, unknown to Reactome, important in beta cells and adipocytes PMID: 19543529. Review of process: PMID: 33692993. Note roles of HOOK1 - PMID: 24284901, PMID: 23589492 and NECC2 - PMID: 30160359 - proteins unknown to Reactome