ukemi
commented
1 year ago - [ ] I stumbled across this when I was looking for GIP signaling and wondered why it wasn't under regulation of insulin secretion. Do we need to take a look at the classification of these in Reactome? It seems there are two axes, the G protein signaling axis and the regulation of insulin secretion axis. Is it not under regulation of insulin secretion because it can do so many things in other tissues? Multiple parentage of subpathways that are parts of more than one higher level pathway is not handled consistently in Reactome. As we gradually make more inter-pathway causal links, and do that more consistently, these problem cases will become modules / cassettes that occur in multiple places in the event hierarchy. But no obvious good one-time fix here.
- [ ] Make mouse model(s): http://noctua.geneontology.org/editor/graph/gomodel:62f58d8800005633? Note that I didn't use the Reactome import as a template for this model, I used the GLP-1 model that I had made for mouse.