ukemi
commented
1 year ago - [ ] Make mouse model: http://noctua.geneontology.org/editor/graph/gomodel:636d9ce800000943\
- [X] I've made this a [GO:0010737] protein kinase A signaling. Should we switch the Reactome BP? DONE
- [X] Looking at the parent of R-HSA-163358, which is R-HSA-163685 Integration of energy metabolism, whose current GO BP term is energy reserve metabolic process (0006112), would a better term be GO:0043467 "regulation of generation of precursor metabolites and energy"? DONE - @ukemi comment if this seems wrong
- [ ] What do you think is responsible for the transport of the proteins in and out of the nucleus? I think we need to investigate this. I suspect it is the pore, but there has to be a regulatory mechanism. Likely an importin. Notes on using relevant publications to revise and extend Reactome ChREBP activation and import reactions and their regulation, involving importin, a 14-3-3 protein, and the nuclear pore, are in this Google Doc: ... David_and_Peter_Notes > energy metabolism integration For the import of mouse PKA into the nucleus, I've annotated Akip1 with a gene, which seems to have a required binding function to PKA to get it into the nucleus according to Sastri et al. 2005. See my model for its inclusion.