Vitamin B1 (thiamin) metabolism (R-HSA-196819)

[ukemi]

• [x] Make mouse models
• [ ] For the creation of the triphosphate (ThTP). No enzyme has been definitively identified, but there is this paper: https://pubmed.ncbi.nlm.nih.gov/2551297/ . Is that good enough evidence to make an ISO? I started to make one in the mouse model but the mutation data in PMID:12379473 argues against it being Ak1.
• [ ] Also in PMID:34827643, the authors 'conclude' that the phosphate donor for the creation of the triphosphate is ADP and the reaction is ThDP + ADP ⇆ ThTP + AMP. What should we do here? Work with Rhea?
• [ ] Do we need to make pathways for AThTP? PMID:34827643.
• [ ] Do we need to make a pathway for the synthesis of ThTP by ATP synthase. Same reviews.