geneontology / pathways2GO

Code for converting between BioPAX pathways and Gene Ontology Causal Activity Models (GO-CAM)
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Add code to disentangle downstream events when the active unit is the same in two different reactions #292

Closed vanaukenk closed 8 months ago

vanaukenk commented 8 months ago

From the 2023-10-12 Reactome2GO meeting at NYU:

In the nuclear signaling by ERBB4 model, regulation of GFAP and S100b are an example of this situation.

dustine32 commented 8 months ago

The red arrows below show how the two causally_upstream_of edges should really be connected: image

ukemi commented 8 months ago

@dustine32 discovered this is a data issue at source. The upstream reaction in Reactome is incorrect and needs to be changed to the S100B-gene binding and not the GFAP gene binding.

deustp01 commented 8 months ago

The upstream reaction in Reactome is incorrect

now fixed