Obsolete all children and add as narrow synonyms. Add SMAD1 homotrimer complex and SMAD1-SMAD4 complex as new narrow synonyms. Stoich comment: SMAD complexes are typically trimeric and contain 1, 2 or 3 different SMAD subunits. Add to def: heterotimers are involved in receptor-mediated gene expression regulation, both as activators and repressors depending on they subunit composition. Homotrimers are probably inactive.
Obsolete all children and add as narrow synonyms. Add SMAD1 homotrimer complex and SMAD1-SMAD4 complex as new narrow synonyms. Stoich comment: SMAD complexes are typically trimeric and contain 1, 2 or 3 different SMAD subunits. Add to def: heterotimers are involved in receptor-mediated gene expression regulation, both as activators and repressors depending on they subunit composition. Homotrimers are probably inactive.