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generatebio / chroma

A generative model for programmable protein design
Apache License 2.0
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Question for CDRs Method #33

Closed Charlesjc-lab closed 6 months ago

Charlesjc-lab commented 6 months ago

When I attempted to redesign the complementarity-determining regions (CDRs) of the antibody, I found that it is only possible to fix multiple epitopes using a method similar to the one depicted in the diagram below. Has anyone tried this approach? Are there any other methods available? 屏幕截图 2023-12-26 152024

wujiewang commented 6 months ago

Thanks for submitting the issue!

you can also provide a binary design mask, I think that will give you more customizability. Also see https://github.com/generatebio/chroma/issues/5

Charlesjc-lab commented 6 months ago

Thanks for the answer!

Design_mask is a smarter approach compared to the method I'm currently using. #5

wujiewang commented 6 months ago

nice! thanks for the feedback. I am closing this for now, but feel free to reopen or open new issues.