Adding sift and polyphen in "enrichment_fields" causes all annotations fail, this is because sift and polyphen are not valid fields name for genome nexus server, so giving sift and polyphen in genome nexus query causes failing annotation.
The sift and polyphen annotations are actually resolved from canonical transcript.
Adding
siftandpolyphenin "enrichment_fields" causes all annotations fail, this is becausesiftandpolyphenare not valid fields name for genome nexus server, so givingsiftandpolyphenin genome nexus query causes failing annotation. Thesiftandpolyphenannotations are actually resolved from canonical transcript.