Pindel can detect breakpoints of large deletions, medium sized insertions, inversions, tandem duplications and other structural variants at single-based resolution from next-gen sequence data. It uses a pattern growth approach to identify the breakpoints of these variants from paired-end short reads.
pindel can detect big insert when -l added. As we know, pindel is based on RP and SR signal , RP can detect insert shorter than library size and SR can only detect insert shorten than read length,
so How does pindel detect big insert ?
pindel can detect big insert when -l added. As we know, pindel is based on RP and SR signal , RP can detect insert shorter than library size and SR can only detect insert shorten than read length, so How does pindel detect big insert ?