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SKAT-O extension #2

Closed henry940926 closed 1 year ago

henry940926 commented 2 years ago

Dear author,

I came across your papers (the extension of burden test and SKAT to multinomial outcomes) which are amazing ideas. I wonder if you have thought/are in the process of extending the SKAT-O method to a multinomial outcome?

Many thanks

Ozvan commented 1 year ago

Many thanks for your message. SKAT p-values are currently obtained through permutation procedures. This makes it difficult to integrate our SKAT extension into SKAT-O which tests for different contributions of SKAT and burden tests. In addition, when SKAT-O is significant, it is often mainly driven by either the burden or the SKAT test. Nevertheless, this question is of great interest and I would be happy to further talk about it.

Best, Ozvan