geohot / corona

Reverse engineering SARS-CoV-2
2.48k stars 480 forks source link

Protein prediction and alignment #11

Open ajuava opened 4 years ago

ajuava commented 4 years ago

Use blastx to predict protein function from amino acid sequence by comparing to other known proteins using homology and preserved domains, im pretty sure you can also install it as a module in python (https://blast.ncbi.nlm.nih.gov/Blast.cgi)

Use clustal Ω to align multiple amino acid or dna sequences (https://www.ebi.ac.uk/Tools/msa/clustalo/)

Also can use jpred to try and infer secondary protein structure (http://www.compbio.dundee.ac.uk/jpred/)

erturkkadir commented 4 years ago

https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173

may give some hint