search

gersteinlab / PsychENCODE_SingleCell_Integrative

Integrative Analyses across 388 human brain samples at single-cell resolution
Other
8 stars 2 forks source link

[Requests] Detailed Methodology on GRN Construction from Supplementary Data #2

Open JiehoonKwak opened 2 weeks ago

JiehoonKwak commented 2 weeks ago

Thank you for providing such high-quality resources. As referenced in the supplementary data of the article, I am seeking a more detailed methodology for constructing GRNs (e.g., metacell, GRN evaluation, etc.). Could you please let me know if these methods are publicly available?

Thank you!

prashantemani commented 2 weeks ago

Thanks for your query. The Supplementary is really the best resource for the GRN construction methodology. I will also consult with my colleagues to see if they have any more information to provide.

JiehoonKwak commented 2 weeks ago

Thanks for your query. The Supplementary is really the best resource for the GRN construction methodology. I will also consult with my colleagues to see if they have any more information to provide.

Thank you so much for your kind response. As you mentioned, I found the supplementary data on GRN construction methodology very helpful. However, as a wet lab scientist, I am not very familiar with the in-depth aspects of gene regulatory networks. May I kindly request the scripts used in the GRN construction? It would be greatly appreciated and immensely helpful for my research.

prashantemani commented 1 week ago

I will pass on your request to my colleagues, but it might take a little time. I do understand it is difficult to replicate the constructions without the scripts, but the scripts need to be properly annotated and uploaded. Please reach out again in a little bit and I will give you an update.