getian107 / PRScs

Polygenic prediction via continuous shrinkage priors
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Documentation clarification: How are blocks defined all 5 populations? #83

Open shz9 opened 1 day ago

shz9 commented 1 day ago

Hi there,

In the Notes describing how the LD reference panels were constructed from the UK Biobank, you state the following:

Define LD blocks using pre-computed cutoff points (http://bitbucket.org/nygcresearch/ldetect-data; AFR: 2,582 blocks; ASN: 1,445 blocks; EUR: 1,703 blocks)

However, LDetect only provides blocks for 3 of the 5 superpopulations defined in the 1000G project (AFR, ASN, EUR). So, I'm wondering which blocks did you use for SAS and AMR samples?

Thank you!

Shadi

getian107 commented 1 day ago

Hi Shadi - We used ASN cutoff points for SAS and AFR cutoff points for AMR as approximations.