gmhhope
commented
1 year ago Include a bigger cohort, specify the distribution of participant ages, sex and race, and include a racially diverse set of individuals.
- This rarely happens lol. But yes, a good suggestion!
I do not understand the reasoning behind using an HIV-virus-based assay for measuring plasma-neutralizing activity and RBD binding alterations.
- Please see https://www.youtube.com/watch?v=J_kTScaVT6c. Around 10:30. The author claims that this is a better assay than just checking reactivity via ELISA to detect how antibody's ability to neutralize certain antigens.
Discussion worksheet
Main Research Question?
The authors want to understand how SARS-CoV-2 antibodies evolve throughout time after COVID-19 infection.
Methods & Data
I consider the methods used to be appropriate for evaluating the questions the authors wanted to address. I believe the data support the authors' conclusions regarding the evolution of antibodies after SARS-CoV-2 infection.
Authors' interpretation
The authors conclude that even six months after infection, antibodies may remain in the body and continue to evolve in a manner that can further contribute to overcoming reinfection. Based on the data presented, I agree with the interpretation of the authors.
Enhancement or next experiment?
Evaluate antibody evolution in individuals who are diagnosed with COVID-19 after having received the vaccination.
confusion? Terms you don't understand?
I do not understand the reasoning behind using an HIV-virus-based assay for measuring plasma neutralizing activity and RBD binding alterations.
Have your own opinions or critiques
Include a bigger cohort, specify the distribution of participant ages, sex and race, and include a racially diverse set of individuals.
I hereby confirm that I have: