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gnn4dr / DRKG

A knowledge graph and a set of tools for drug repurposing
Apache License 2.0
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Interests about repurposing tasks #25

Open zhaohan-xi opened 2 years ago

zhaohan-xi commented 2 years ago

Hi Dear Author,

Your repurposing KG looks great and comprehensive. I'm curious about the use of this KG, especially on repurposing tasks. If my understanding is correct, the "Compound" entities refer to "Drug" in the collected sources; the repurposing means find new targets/functions/effects of a known drug.

For example, we know a drug is effective on some diseases, targets some genes, and has some side effects, we want to explore more diseases it will work, and also potential targeted genes, and even more side effects it may contain...Are those the repurposing tasks?

ishaan-mehta commented 2 years ago

Repurposing generally refers to the task of finding existing drugs that can be used to treat diseases different than the ones they are currently used to treat. With knowledge graphs, we can do drug repurposing through link prediction. Under the link prediction umbrella, there is drug repurposing, but also other tasks you mention, such as finding side effects of drugs.