Modeling with a defined template

[almeida85]

Hello,

I am modeling a multimer composed of a monomer that binds to a homodimer. The monomer in solution adopts a conformation but when bound to the dimer, it suffers a big conformational change. My goal is to model the monomer in that conformation bound to the dimer.

There are structures of the monomer in solution and a homolog that is in the conformation that I am interested in. Is it possible to define a particular template with a conformation of interest to model a particular chain of a multimer? Or, is it possible to exclude templates for the prediction?

Thanks in advance for the help

[tjonesster]

This functionality should be baked into colabfold. Don't think that it is currently supported in stock Alphafold

[almeida85]

Thanks for the reply!