gravelLab / tracts

A set of tools for modelling ancestry patterns along the genome.
GNU General Public License v2.0
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4 populations sample models required? #8

Closed wjaratlerdsiri closed 4 years ago

wjaratlerdsiri commented 8 years ago

Dear Simon,

I have tried to run my admixed population with 2 and 3-population models in your document. However, structure analyses indicated 4 ancestral populations in my cohort.

Could you suggest me how I can find a sample script for 4-population tracts analyses?

Thankyou for your great software and help.

Cheers, James

sgravel commented 8 years ago

I have never run more than 3 populations, because I have never found a situation where we could reliably assign more than 3 ancestries. I forget if the underlying code can handle more than three populations, I suspect that there might be a few hiccups if you did that, but they would be easily fixable. If you feel confident that you can reliably assign four local ancestries, I can help you make it work.

One workaround would be to combine two of the four ancestries (typically, the most difficult to distinguish) and treat them as a single ancestry.

On Sun, Nov 13, 2016 at 12:50 AM, wjaratlerdsiri notifications@github.com wrote:

Dear Simon,

I have tried to run my admixed population with 2 and 3-population models in your document. However, structure analyses indicated 4 ancestral populations in my cohort.

Could you suggest me how I can find a sample script for 4-population tracts analyses?

Thankyou for your great software and help.

Cheers, James

— You are receiving this because you are subscribed to this thread. Reply to this email directly, view it on GitHub https://github.com/sgravel/tracts/issues/8, or mute the thread https://github.com/notifications/unsubscribe-auth/AGnPhFQD7gb5z7xI3gWKAQbYVh3fU_lAks5q9qVCgaJpZM4Kwnct .

wjaratlerdsiri commented 7 years ago

Thanks Simon,

Can I contact you via this email, simon.gravel@mcGill.ca ? I like to give you more details.

Regards, James

sgravel commented 7 years ago

sure.

On Thu, Nov 17, 2016 at 11:45 PM, wjaratlerdsiri notifications@github.com wrote:

Thanks Simon,

Can I contact you via this email, simon.gravel@mcGill.ca ? I like to give you more details.

Regards, James

— You are receiving this because you commented. Reply to this email directly, view it on GitHub https://github.com/sgravel/tracts/issues/8#issuecomment-261447818, or mute the thread https://github.com/notifications/unsubscribe-auth/AGnPhG-4RZLTvka3ibwF_xDraFu7iprvks5q_S2BgaJpZM4Kwnct .

Simon Gravel McGill University and Génome Québec Innovation Centre Dept of Human Genetics, McGill University 740 Dr. Penfield – Room 7206 Montréal, Québec, H3A 1A4 514-398-4400 #0753

wjaratlerdsiri commented 7 years ago

I sent some details to the email above. Let me know if you need to try the data.

Thanks, James