New Paper (Other): The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

[ajlee21]

Title: The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

General Information

Please paste a link to the paper or a citation here:

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114094/

What is the paper's Manubot-style citation?

Citation: doi:10.1016/j.antiviral.2020.104742

Is this paper primarily relevant to Background or Pathogenesis?

• [ ] Background
• [x] Pathogenesis
• [ ] Methods

Please list some keywords (3-10) that help identify the relevance of this paper to COVID-19

• keyword 1 (replace me, copy and paste more than three if needed)
• keyword 2 (replace me, copy and paste more than three if needed)
• keyword 3 (replace me, copy and paste more than three if needed)

Which areas of expertise are particularly relevant to the paper?

• [x] virology
• [ ] epidemiology
• [ ] biostatistics
• [x] immunology
• [ ] pharmacology
• [ ] other:

Summary

Suggested questions to answer about each paper:

• What did they analyze?
• What methods did they use?
• Does this paper study COVID-19, SARS-CoV-2, or a related disease and/or virus?
• What is the main finding (or a few main takeaways)?
• What does this paper tell us about the background and/or diagnostics/therapeutics for COVID-19 / SARS-CoV-2?
• Do you have any concerns about methodology or the interpretation of these results beyond this analysis?

Any comments or notes?

Paper cited during Penn COVID symposia when talking about increased virulence of SARS-CoV2 due to fusion site

[agitter]

Thanks @ajlee21. I edited the Manubot citation to remove the space in doi:10.1016/j.antiviral.2020.104742. That was causing problems in other papers where contributors copy/pasted the citation.