New Paper (Other): [The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein harbors a conserved BH3-like motif]

[marouenbg]

Title: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein harbors a conserved BH3-like motif

General Information

Please paste a link to the paper or a citation here:

Link: https://www.biorxiv.org/content/10.1101/2020.04.09.033522v1

What is the paper's Manubot-style citation?

Citation: [@doi:10.1101/2020.04.09.033522]

Is this paper primarily relevant to Background or Pathogenesis?

• [ ] Background
• [x] Pathogenesis
• [ ] Methods

Please list some keywords (3-10) that help identify the relevance of this paper to COVID-19

• keyword 1 Protein E
• keyword 2 T cell
• keyword 3 Envelope proteins

Which areas of expertise are particularly relevant to the paper?

• [x] virology
• [ ] epidemiology
• [ ] biostatistics
• [x] immunology
• [ ] pharmacology
• [ ] other:

[marouenbg]

Summary

Suggested questions to answer about each paper:

• What did they analyze? They analyzed the sequence of E protein of SARS-CoV-2 and found that it has BH3-like motif.
• What methods did they use? Sequence analysis, bioinformatics.
• Does this paper study COVID-19, SARS-CoV-2, or a related disease and/or virus?
• What is the main finding (or a few main takeaways)? BH3 inhibit the Bcl-xl which has anti-apoptotic properties in T cells.
• What does this paper tell us about the background and/or diagnostics/therapeutics for COVID-19 / SARS-CoV-2? The paper tell us the potentially, SARS-CoV-2 may induce apoptosis in T cells.
• Do you have any concerns about methodology or the interpretation of these results beyond this analysis? I am not totally knowledgeable about sequence analysis/immunology so I can't assess the methodology of the paper. However, the claims are so important that, if confirmed, It could be a game changer in our understanding of the mechanism of action.

  Any comments or notes?