New Paper (Other): CD147 Is a Signaling Receptor for Cyclophilin B

[matfax]

Title: CD147 Is a Signaling Receptor for Cyclophilin B

General Information

Please paste a link to the paper or a citation here:

Link: https://doi.org/10.1006/bbrc.2001.5847

What is the paper's Manubot-style citation?

Citation: doi:10.1006/bbrc.2001.5847

Is this paper primarily relevant to Background or Pathogenesis?

• [x] Background
• [ ] Pathogenesis
• [ ] Methods

Please list some keywords (3-10) that help identify the relevance of this paper to COVID-19

• CD147
• CypA
• CypB
• Ca2+
• ERK

Please note the publication / review status

• [ ] Pre-print
• [ ] New Peer-Reviewed Paper
• [x] Peer-Reviewed Paper Pre-2020

Which areas of expertise are particularly relevant to the paper?

• [ ] virology
• [ ] epidemiology
• [ ] biostatistics
• [x] immunology
• [ ] pharmacology
• [ ] other:

[matfax]

Summary

Yurchenko et al. analyzed the role of CD147 as cell entry receptor for CypA and CypB in this study, mainly how CypB differed from CypA. Their key findings are as follows:

• CypA and CypB induced intracellular Ca2+ flux. CypB showed stronger dose effectivity.
• CypB induced ERK phosphorylation.
• CypB induced chemotaxis for CD147-expressing cells but not pcDNA cells.
• CD147 antibodies inhibited CypB-mediated chemotaxis.