Open rando2 opened 4 years ago
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(Suggestion & initial draft by @SiminaB , edited by @agitter )
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Questions to Think About From @dziakj1:
Hello everybody! I was watching a lecture on Youtube from Dr. Britt Glaunsinger of Berkeley: https://www.youtube.com/watch?v=8_bOhZd6ieM At the end (about 1:00:00), she listed six questions which she considered especially important for future basic science research on SARS-CoV-2:
- "What is the role of the polybasic site in the spike protein in CoV-2 transmission?"
- "What are the pathways involved in CoV-induced memberane remodeling, and how do RTCs temporally and functionally coordinate various stages of the viral lifecycle?"
- "What are the biochemical activities and roles of the various proteins that form the replication transcription complex, and how do they coordinate genome replication vs. transcription?"
- "How do CoVs maintain such a large genome and still have sufficient mutation rates for adaptation and trans-species movement?"
- "What are the functions of the CoV-2 accessory proteins, and how do they impact the in vivo growth and virulence of the virus?"
- "Will CoV-2 infected individuals (or vaccines) mount protective long-term immune responses?" I just wanted to pass this along in case it gave anyone any useful ideas on what topics to focus on in reviewing.
Hello everybody! In case anyone missed it, a narrative review of pharmacological treatments for COVID-19 just came out in JAMA: https://jamanetwork.com/journals/jama/fullarticle/2764727
This new curated and annotated resource from Kathryn Grabowski at Johns Hopkins (@JHU_NCRC on Twitter) looks extremely promising: Novel Coronavirus Research Compendium https://docs.google.com/spreadsheets/d/e/2PACX-1vRpGhzDhyroswkqKMR9YkxtueVDq7hLjQuDMlsxjrBt8iLyJnZGu7NvBzawB_aNTnhq7ALuhxA1-wMc/pubhtml They say they will launch a website (not just a Google doc) very soon.
A great thing to do is to go through @rdvelazquez list of preprints that need issues opened in #227 Use the appropriate New Paper template to open an issue for the papers and then comment on #227 saying which papers you created issues for
Key questions to think about: https://www.idsociety.org/globalassets/idsa/public-health/covid-19/idsa-covid-19-key-research-qs.pdf
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