greenelab / pdx_exomeseq

Pipeline analysis for whole exome sequencing of pancreatic cancer PDX models
MIT License
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Adding pipeline steps and logic for human only variant calling #69

Closed gwaybio closed 6 years ago

gwaybio commented 6 years ago

refs #67

This PR stores the logic and infrastructure to run the human tissue samples through a human-only WES pipeline. Previously, all samples (including all patient derived xenografts) are run through the same pipeline, which aligns to both human and mouse, and then performs a disambiguation step.

Our collaborators were concerned with false positive variants creeping through into the human samples that failed to be filtered.