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griffithlab / civic-client

Web client for CIViC: Clinical Interpretations of Variants in Cancer
MIT License
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Add "Dominant Negative" to Functional Clinical Significance #1189

Closed arpaddanos closed 5 years ago

arpaddanos commented 5 years ago

CIViC is currently tasked to capture and annotate TP53 functional evidence. Evidence types have broadly fallen into Gain of Function, Loss of Function, Neomorphic and Dominant Negative (DN) annotations. We currently lack in CIViC the capability to annotate the DN category, and I suggest this category be added to the Clinical Significance of the Functional Evidence Type.

arpaddanos commented 5 years ago

The following search of functional EIDs with evidence explicitly discussing DN effects, yet lacking consistent annotations, demonstrates the need for a consistent annotation category for this type of evidence.

https://civicdb.org/search/evidence/253caffa-f6db-4571-a062-34e19a212c81

kkrysiak commented 5 years ago

@arpaddanos to figure out icon, tool tip, help text.