Add field to track number of individuals associated with an evidence item

[susannasiebert]

@kkrysiak can you please provide more details for this issue?

• How would this field be used? E.g., database/calcualted field only, display only, browse, advanced search, stats?
• If we want to display this metric, where would it appear?
• What types of interactions of a user with an evidence item would be counted? E.g., submit, accept, suggested change, accept/reject suggested change, comment, flag?

[kkrysiak]

We need to discuss this as a group since this is a complex thing.

[kkrysiak]

One suggestion would be the number of individuals with a variant. This would translate well for clinical and case study levels for both germline and somatic contexts.

[kkrysiak]

Interesting use cases.

• Evidence summarizing 7 patients with the mutation, 7 with major cytogenetic response, 3 with complete molecular response
• VHL 2 affected with 1 unaffected individual
• Large clinical trials with 40 unmutated and 7 mutated individuals
• Predictive - number of CR, PR, SD, PD

[malachig]

This field, could be called study size

[malachig]

It was also proposed that we could have a list of counts (study size, number of families, treatment arm size, etc.) and each fo these could have a count assigned.

[arpaddanos]

This issue is relevant for questions of associating HPO phenotypes to occurrences of the mutation, in a family, or down to the individual patient. It also might associate occurrences of the mutation with a VHL phenotype in general with no phenotype at all.

[arpaddanos]

A discussion relevant to this will occur in July 2020 with the VHL group.