interaction network diffusion of oncogenicity metric value of variants to find signalling neighborhoods

[dexterpratt]

Interpret the potential interactions of variant genes using heat diffusion methodology.

Add initial heat of variants to corresponding nodes of a protein-protein interaction network, proportional to the oncogenicity metric value for each variant.

This will produce a subnetwork of the interaction network that is focused on the most relevant proteins/genes

Conjecture: this network could then be augmented via addition of drug-variant / drug-gene interaction links to suggest relevant therapies, one that may expose drug effects that affect multiple variants.

[dexterpratt]

Cytoscape provides diffusion tools. NDEx can provide a CIViC drug-variant network and a variety of protein-protein interactions networks for use in Cytoscape