search_variants_by_coordinates() does not work (v2.0.0)

[mapo9]

Hi,

version 2.0.0. I was trying to use civic.search_variants_by_coordinates() as seen in the provided Genie example. Command:

coords = civic.CoordinateQuery(chr='7', start=140453136, stop=140453136) civic.search_variants_by_coordinates(coords, search_mode='any')

However, this is not possible as I get the following error message:

`AttributeError Traceback (most recent call last) Cell In [13], line 2 1 test = civic.CoordinateQuery(chr='7', start=140453136, stop=140453136) ----> 2 civic.search_variants_by_coordinates(test, search_mode='query_encompassing')

File ~/miniconda3/envs/work/lib/python3.10/site-packages/civicpy/civic.py:2085, in search_variants_by_coordinates(coordinate_query, search_mode) 2083 chromosome = str(coordinate_query.chr) 2084 # overlapping = (start <= ct.stop) & (stop >= ct.start) -> 2085 left_idx = chr_idx.searchsorted(chromosome) 2086 right_idx = chr_idx.searchsorted(chromosome, side='right') 2087 chr_ct_idx = chr_idx[left_idx:right_idx].index

AttributeError: 'NoneType' object has no attribute 'searchsorted'`

[acoffman]

Hi, thanks for reporting this. I can confirm that I am able to replicate this issue and am looking into it!

[acoffman]

Hi @mapo9, we have identified the issue and its related to the generated cache file that civicpy downloads.

If you remove your local copy of the cache which is stored in ~/.civicpy and perform the following steps:

from civicpy import civic
civic.load_cache()

coords = civic.CoordinateQuery(chr='7', start=140453136, stop=140453136)
civic.search_variants_by_coordinates(coords, search_mode='any')

You should get results successfully now. Apologies for the trouble and let us know if you have any further issues!

Thanks, Adam