griffithlab / pVACtools

http://www.pvactools.org
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QUESTION: How to integrate netchop results to aditionnally filter possible peptides #1064

Open PierreLaplante opened 6 months ago

PierreLaplante commented 6 months ago

Hello, I would like to know your current take on integrating the clivage score in the pipeline. I ran the downstream filtering from the all_epitopes.tsv myself, and wanted to see results from NetChop with the predicted neoantigens. With my current experiment, it seems that most of the PASS neoantigens I obtained running the pipeline report an internal clivage site above 0.5. It seems inacurate to just discard them all, so I wanted to know how you implemented this score in the pipeline as downstream filtering. Thank you.