gusevlab / fusion_twas

methods for functional summary-based imputation
http://gusevlab.org/projects/fusion/
GNU General Public License v3.0
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issue with FUSION.post_process.R --omnibus #58

Open yangrousong opened 1 year ago

yangrousong commented 1 year ago

First, thanks @sashagusev for developing and maintaining this tool.I just got into the TWAS field, so i have many issue. 1. When i combine the two files into on one file and run FUSION.post_process.R --omnibus, I found that there are no graphs in the generated results. The code I ran is as follows: Rscript $PathSoftware/FUSION.post_process.R --omnibus \ --sumstats $PathSummary/SFC${PhenoName}.txt \ --input $OutPath/SFC${PhenoName}.${Chr}.top \ --out $OutPath_PostAnalysis/SFC${PhenoName}.${Chr}.top.analysis \ --ref_ld_chr $PathSoftware/LDREF/1000G.EUR. \ --chr $Chr \ --plot \ --locus_win 100000.

  1. When I Test for effect in CMC.BRAIN.RNASEQ_SPLICING (ZNF561) and TCGA-GBM.TUMOR.ZNF846_162993.wgt.RDat TCGA-SARC.TUMOR.ZNF846_162993.wgt.RDat TCGA-HNSC.TUMOR.ZNF846_162993.wgt.RDat TCGA-LGG.TUMOR.ZNF561_93134.wgt.RDat TCGA-LGG.TUMOR.ZNF846_162993.wgt.RDat. The result (.CORR.dat) only appeared CMC.BRAIN.RNASEQ_SPLICING (ZNF561) and TCGA-LGG.TUMOR.ZNF561_93134.wgt.RDat as follow: GENE REF1 REF2 CORR ZNF561 CMC.BRAIN.RNASEQ_SPLICING TCGA-LGG.TUMOR -0.701 I don't know how to understand this part of the content, perhaps you can tell me where to go to seek a solution.