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hallowkm / RxODE

RxODE is an R package that facilitates easy simulations in R
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Large dose dosen't work. Error: could not solve ODE, IDID=-1 #11

Closed Sibojang9 closed 7 years ago

Sibojang9 commented 7 years ago

It works with dose equal =1000, but doesn't work with dose equal=10000. Sounds weird. Error: snap3

` library(RxODE) ode <- " C2 = A2/V2 ; C5=A5/V5 ; d/dt(A1) = - Kabs*A1 ; d/dt(A2) = Kabs*A1- K23*A2 - K32*A3 - K24*A2 + K42*A4 -K20*A2 ; d/dt(A3) = K23*A2 - K32*A3; d/dt(A4) = K24*A2 - K42*A4 ; d/dt(A5) = (VMAX/(KM+C2))*C2- KOUT*A5 ; "

mod1 <- RxODE(model = ode, modName = "mod1")
theta <- c(
Kabs= 3, CL = 12.4, V2 =20, V3 =26, V4 = 21.6,Q =10,Q2 =0 ,
K20 =0.62, K23 = 0.95, K32 =0.73, K24 = 0, K42 = 0, VMAX=0.624, KM=7.4, V5=16, KOUT =0.394 )

ev <- eventTable() ev$add.dosing(dose = 10000 ,nbr.doses=1,dosing.to=1) ev$add.sampling(0:20) x <- mod1$run(theta, ev)
`

wwang-at-github commented 7 years ago

you have a bug in your ODEs. should be: d/dt(A2) = KabsA1- K23A2 + K32A3 - K24A2 + K42A4 -K20A2 ;

On Thu, May 25, 2017 at 5:53 PM, Sibo Jiang notifications@github.com wrote:

It works with dose equal =1000, but doesn't work with dose equal=10000. Sounds weird. Error: [image: snap3] https://cloud.githubusercontent.com/assets/11802171/26472030/56d2ba34-4172-11e7-905a-028058dc86bf.jpg

library(RxODE) ode <- " C2 = A2/V2 ; C5=A5/V5 ; d/dt(A1) = - Kabs A1 ; d/dt(A2) = KabsA1- K23A2 - K32A3 - K24A2 + K42A4 -K20 A2 ; d/dt(A3) = K23A2 - K32 A3; d/dt(A4) = K24A2 - K42A4 ; d/dt(A5) = (VMAX/(KM+C2))C2- KOUT*A5 ; "

mod1 <- RxODE(model = ode, modName = "mod1")

theta <- c( Kabs= 3, CL = 12.4, V2 =20, V3 =26, V4 = 21.6,Q =10,Q2 =0 , K20 =0.62, K23 = 0.95, K32 =0.73, K24 = 0, K42 = 0, VMAX=0.624, KM=7.4, V5=16, KOUT =0.394 )

ev <- eventTable() ev$add.dosing(dose = 10000 ,nbr.doses=1,dosing.to=1) ev$add.sampling(0:20) x <- mod1$run(theta, ev)

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Sibojang9 commented 7 years ago

Thank you so much for your input. It was fixed once I changed the code.