hammer
commented
7 years ago Related work
- Immunologic heterogeneity of tumor-infiltrating lymphocyte composition in primary melanoma
- Modelling the spatial heterogeneity and molecular correlates of lymphocytic infiltration in triple-negative breast cancer (2015)
- Immune and T cell receptor heterogeneity in distinct tumors within individual melanoma patients (2015)
- Mapping spatial heterogeneity in the tumor microenvironment: a new era for digital pathology (2015)
Ben has a new assay that can measure expression levels for 100 - 1k transcripts with very low input material and cost. He also has some micro-dissection technology to sample a small piece of tissue from a larger tumor biopsy.
We could give him a list of 100 - 1k genes that best discriminate immune + stromal infiltration; once he has that panel, we could sample from multiple locations on a tumor and measure the spatial heterogeneity of immune + stromal infiltration.